Noncanonical Hedgehog Signaling

Overview

Journal Vitam Horm

Specialties Endocrinology
Nutritional Sciences

Date 2012 Mar 7

PMID 22391299

Citations 100

Authors

Donna Brennan

Xiaole Chen

Lan Cheng

My Mahoney

Natalia A Riobo

Affiliations

Soon will be listed here.

Abstract

The notion of noncanonical hedgehog (Hh) signaling in mammals has started to receive support from numerous observations. By noncanonical, we refer to all those cellular and tissue responses to any of the Hh isoforms that are independent of transcriptional changes mediated by the Gli family of transcription factors. In this chapter, we discuss the most recent findings that suggest that Patched1 can regulate cell proliferation and apoptosis independently of Smoothened (Smo) and Gli and the reports that Smo modulates actin cytoskeleton-dependent processes such as fibroblast migration, endothelial cell tubulogenesis, axonal extension, and neurite formation by diverse mechanisms that exclude any involvement of Gli-dependent transcription. We also acknowledge the existence of less stronger evidence of noncanonical signaling in Drosophila.

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