Crosstalk Between Wnt/β-catenin and Hedgehog/Gli Signaling Pathways in Colon Cancer and Implications for Therapy

Overview

Journal Cancer Biol Ther

Specialties Oncology
Pharmacology

Date 2015 Feb 19

PMID 25692617

Citations 57

Authors

Li Song

Zhuo-Yu Li

Wei-Ping Liu

Mei-Rong Zhao

Affiliations

Soon will be listed here.

Abstract

Wnt/β-catenin and Hedgehog/Gli signalings play key roles in multiple biogenesis such as embryonic development and tissue homeostasis. Dysregulations of these 2 pathways are frequently found in most cancers, particularly in colon cancer. Their crosstalk has been increasingly appreciated as an important mechanism in regulating colon cancer progression. Our studies into the link between Wnt/β-catenin and Hedgehog/Gli signalings in colon cancer revealed several possible crosstalk points and suggested potential therapeutic strategies for colon cancer.

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