Regulation of Sex Hormone Receptors in Sexual Dimorphism of Human Cancers

Overview

Journal Cancer Lett

Specialty Oncology

Date 2018 Sep 18

PMID 30223066

Citations 10

Authors

Daoshan Zheng

Cecilia Williams

Jeremy A Vold

Justin H Nguyen

Denise M Harnois

Sanjay P Bagaria

Sarah A McLaughlin

Zhaoyu Li

Affiliations

Soon will be listed here.

Abstract

Gender differences in the incidences of cancers have been found in almost all human cancers. However, the mechanisms that underlie gender disparities in most human cancer types have been under-investigated. Here, we provide a comprehensive overview of potential mechanisms underlying sexual dimorphism of each cancer regarding sex hormone signaling. Fully addressing the mechanisms of sexual dimorphism in human cancers will greatly benefit current development of precision medicine. Our discussions of potential mechanisms underlying sexual dimorphism in each cancer will be instructive for future cancer research on gender disparities.

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