Estrogen Receptor-beta Genetic Variations and Overall Survival in Patients with Locally Advanced Gastric Cancer

Overview

Journal Pharmacogenomics J

Specialties Genetics
Molecular Biology
Pharmacology

Date 2015 Oct 28

PMID 26503819

Citations 8

Authors

Y Sunakawa

S Cao

M D Berger

S Matsusaka

D Yang

W Zhang

Y Ning

A Parekh

S Stremitzer

A Mendez

S Okazaki

T Wakatsuki

M Azuma

K Shimada

M Watanabe

W Koizumi

A H Wu

H-J Lenz

Affiliations

Soon will be listed here.

Abstract

Estrogen has been shown not only to reduce the incidence of colorectal cancer but also gastric cancer (GC). Polymorphisms in estrogen receptor β gene, ESR2, correlate with colorectal cancer survival. To better understand the role of ESR2 in GC, genomic DNA extracted from 169 Japanese patients and 172 patients from Los Angeles County (LAC) was analyzed for association of overall survival (OS) with three ESR2 polymorphisms, which are of biological significance using multivariable Cox proportional hazard regression. ESR2 rs1271572 (C>A) and rs3020443 (T>G) had univariate and multivariable associations with OS in the Japanese cohort, whereas the C allele of ESR2 rs2978381 (T>C) predicted favorable OS in the Japanese cohort but worse OS in the LAC cohort. The interaction term of the ESR2 rs2978381 and cohort group reached statistical significance. Our study provides evidence that genetic variations in ESR2 gene are significantly associated with survival in patients with locally advanced GC.

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References

Zhao C, Lam E, Sunters A, Enmark E, Tamburo De Bella M, Coombes R . Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylation. Oncogene. 2003; 22(48):7600-6. DOI: 10.1038/sj.onc.1207100. View

Frise S, Kreiger N, Gallinger S, Tomlinson G, Cotterchio M . Menstrual and reproductive risk factors and risk for gastric adenocarcinoma in women: findings from the canadian national enhanced cancer surveillance system. Ann Epidemiol. 2006; 16(12):908-16. DOI: 10.1016/j.annepidem.2006.03.001. View

. Polymorphisms in genes of the steroid receptor superfamily modify postmenopausal breast cancer risk associated with menopausal hormone therapy. Int J Cancer. 2009; 126(12):2935-46. DOI: 10.1002/ijc.24892. View

Passarelli M, Phipps A, Potter J, Makar K, Coghill A, Wernli K . Common single-nucleotide polymorphisms in the estrogen receptor β promoter are associated with colorectal cancer survival in postmenopausal women. Cancer Res. 2012; 73(2):767-75. PMC: 3588850. DOI: 10.1158/0008-5472.CAN-12-2484. View

Xu C, Guo J, Jiang Z, Xie S, Shen J, Shen J . Prognostic role of estrogen receptor alpha and estrogen receptor beta in gastric cancer. Ann Surg Oncol. 2010; 17(9):2503-9. DOI: 10.1245/s10434-010-1031-2. View

Rose D, Vona-Davis L . Interaction between menopausal status and obesity in affecting breast cancer risk. Maturitas. 2010; 66(1):33-8. DOI: 10.1016/j.maturitas.2010.01.019. View

Hildebrand J, Jacobs E, Campbell P, McCullough M, Teras L, Thun M . Colorectal cancer incidence and postmenopausal hormone use by type, recency, and duration in cancer prevention study II. Cancer Epidemiol Biomarkers Prev. 2009; 18(11):2835-41. DOI: 10.1158/1055-9965.EPI-09-0596. View

Saville B, Wormke M, Wang F, Nguyen T, Enmark E, Kuiper G . Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements. J Biol Chem. 2000; 275(8):5379-87. DOI: 10.1074/jbc.275.8.5379. View

Li L, Yeh C, Nojima D, Dahiya R . Cloning and characterization of human estrogen receptor beta promoter. Biochem Biophys Res Commun. 2000; 275(2):682-9. DOI: 10.1006/bbrc.2000.3363. View

10.

Treeck O, Elemenler E, Kriener C, Horn F, Springwald A, Hartmann A . Polymorphisms in the promoter region of ESR2 gene and breast cancer susceptibility. J Steroid Biochem Mol Biol. 2009; 114(3-5):207-11. DOI: 10.1016/j.jsbmb.2009.02.012. View

11.

Castiglione F, Taddei A, Rossi DeglInnocenti D, Buccoliero A, Bechi P, Garbini F . Expression of estrogen receptor beta in colon cancer progression. Diagn Mol Pathol. 2008; 17(4):231-6. DOI: 10.1097/PDM.0b013e3181656d67. View

12.

Shah M, Khanin R, Tang L, Janjigian Y, Klimstra D, Gerdes H . Molecular classification of gastric cancer: a new paradigm. Clin Cancer Res. 2011; 17(9):2693-701. PMC: 3100216. DOI: 10.1158/1078-0432.CCR-10-2203. View

13.

Moon Y, Park S, Sohn J, Kang D, Koo J, Park H . Clinical significance of progesterone receptor and HER2 status in estrogen receptor-positive, operable breast cancer with adjuvant tamoxifen. J Cancer Res Clin Oncol. 2011; 137(7):1123-30. DOI: 10.1007/s00432-011-0976-2. View

14.

Guo J, Xu C, Jiang Z, Dong M, Xie S, Shen J . Estrogen receptor beta variants mRNA expressions in gastric cancer tissues and association with clinicopathologic parameters. Hepatogastroenterology. 2011; 57(104):1584-8. View

15.

Crew K, Neugut A . Epidemiology of gastric cancer. World J Gastroenterol. 2006; 12(3):354-62. PMC: 4066052. DOI: 10.3748/wjg.v12.i3.354. View

16.

Hogan A, Collins D, Baird A, Winter D . Estrogen and gastrointestinal malignancy. Mol Cell Endocrinol. 2009; 307(1-2):19-24. DOI: 10.1016/j.mce.2009.03.016. View

17.

Wang M, Pan J, Song G, Chen H, An L, Qu S . Altered expression of estrogen receptor alpha and beta in advanced gastric adenocarcinoma: correlation with prothymosin alpha and clinicopathological parameters. Eur J Surg Oncol. 2006; 33(2):195-201. DOI: 10.1016/j.ejso.2006.09.009. View

18.

Kim C, Golden S, Mather K, Laughlin G, Kong S, Nan B . Racial/ethnic differences in sex hormone levels among postmenopausal women in the diabetes prevention program. J Clin Endocrinol Metab. 2012; 97(11):4051-60. PMC: 3485611. DOI: 10.1210/jc.2012-2117. View

19.

Evans D, Cardon L . A comparison of linkage disequilibrium patterns and estimated population recombination rates across multiple populations. Am J Hum Genet. 2005; 76(4):681-7. PMC: 1199305. DOI: 10.1086/429274. View

20.

Vaidya D, Dobs A, Gapstur S, Golden S, Cushman M, Liu K . Association of baseline sex hormone levels with baseline and longitudinal changes in waist-to-hip ratio: Multi-Ethnic Study of Atherosclerosis. Int J Obes (Lond). 2012; 36(12):1578-84. PMC: 3342434. DOI: 10.1038/ijo.2012.3. View