Natural Peptides in Drug Discovery Targeting Acetylcholinesterase

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2018 Sep 16

PMID 30217053

Citations 16

Authors

Vivitri Prasasty

Muhammad Radifar

Enade Istyastono

Affiliations

Soon will be listed here.

Abstract

Acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (AChE) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of Alzheimer's disease (AD). Natural peptides have received considerable attention as biologically important substances as a source of AChE inhibitors. These natural peptides have high potential pharmaceutical and medicinal values due to their bioactivities as neuroprotective and neurodegenerative treatment activities. These peptides have attracted great interest in the pharmaceutical industries, in order to design potential peptides for use in the prophylactic and therapy purposes. Some natural peptides and their derivatives have high commercial values and have succeeded in reaching the pharmaceutical market. A large number of peptides are already in preclinical and clinical pipelines for treatment of various diseases. This review highlights the recent researches on the various natural peptides and future prospects for AD management.

Citing Articles

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