Sinulariapeptide F, a New Peptide from Culture Broth of Marine-derived Fungus Simplicillium Sp. SCSIO 41222

Overview

Journal J Antibiot (Tokyo)

Specialties Infectious Diseases
Pharmacology

Date 2024 Oct 25

PMID 39455819

Authors

Yan-Chun He

Meng-Qin Wang

Qing-Qing Tie

Xiao-Wen Huang

Yong-Hong Liu

Yun-Qiu Li

Bin Yang

Affiliations

Soon will be listed here.

Abstract

One new compound named sinulariapeptide F (1) together with one known butyrolactone (2) and seven known peptides (3-9) were isolated from the fungus Simplicillium sp. SCSIO 41222. Their structures and absolute configurations were established using HRESIMS, NMR spectroscopy (H, C, HSQC, HMBC) and marfey's method. All of these compounds were assessed their inhibitory activity of acetylcholinesterase (AChE) and pancreatic lipase (PL). Compounds 4 and 6 were selected to test for the inhibitory activity against programmed cell death-1 (PD-1)/ programmed cell death-ligand 1 (PD-L1). The results indicated that compound 4 displayed potent inhibition activity against PD-1/ PD-L1 with an IC value of 0.656 μM. Furthermore, the docking analysis demonstrated the interactions between 4 and proteins, suggesting PD-L1 to be a probable target for compound 4.

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