Statistical Research on the Bioactivity of New Marine Natural Products Discovered During the 28 Years from 1985 to 2012

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2015 Jan 10

PMID 25574736

Citations 90

Authors

Yiwen Hu

Jiahui Chen

Guping Hu

Jianchen Yu

Xun Zhu

Yongcheng Lin

Shengping Chen

Jie Yuan

Affiliations

Soon will be listed here.

Abstract

Every year, hundreds of new compounds are discovered from the metabolites of marine organisms. Finding new and useful compounds is one of the crucial drivers for this field of research. Here we describe the statistics of bioactive compounds discovered from marine organisms from 1985 to 2012. This work is based on our database, which contains information on more than 15,000 chemical substances including 4196 bioactive marine natural products. We performed a comprehensive statistical analysis to understand the characteristics of the novel bioactive compounds and detail temporal trends, chemical structures, species distribution, and research progress. We hope this meta-analysis will provide useful information for research into the bioactivity of marine natural products and drug development.

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