Developmental Programming of the Metabolic Syndrome: Can We Reprogram with Resveratrol?

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2018 Sep 12

PMID 30200293

Citations 25

Authors

You-Lin Tain

Chien-Ning Hsu

Affiliations

Soon will be listed here.

Abstract

Metabolic syndrome (MetS) is a mounting epidemic worldwide. MetS can start in early life, in a microenvironment that is now known as the developmental origins of health and disease (DOHaD). The concept of DOHaD also offers opportunities for reprogramming strategies that aim to reverse programming processes in early life. Resveratrol, a polyphenolic compound has a wide spectrum of beneficial effects on human health. In this review, we first summarize the epidemiological and experimental evidence supporting the developmental programming of MetS. This review also presents an overview of the evidence linking different molecular targets of resveratrol to developmental programming of MetS-related disorders. This will be followed by studies documenting resveratrol as a reprogramming agent to protect against MetS-related disorders. Further clinical studies are required in order to bridge the gap between animal models and clinical trials in order to establish the effective dose and therapeutic duration for resveratrol as a reprogramming therapy on MetS disorders from developmental origins.

Citing Articles

Resveratrol Butyrate Esters Reduce Hypertension in a Juvenile Rat Model of Chronic Kidney Disease Exacerbated by Microplastics.

Huang Y, Hsu C, Hou C, Chen S, Tain Y Nutrients. 2024; 16(23).

PMID: 39683469 PMC: 11643537. DOI: 10.3390/nu16234076.

Early Life Programming of Adipose Tissue Remodeling and Browning Capacity by Micronutrients and Bioactive Compounds as a Potential Anti-Obesity Strategy.

Bonet M, Ribot J, Sanchez J, Palou A, Pico C Cells. 2024; 13(10.

PMID: 38786092 PMC: 11120104. DOI: 10.3390/cells13100870.

The Impact of the Aryl Hydrocarbon Receptor on Antenatal Chemical Exposure-Induced Cardiovascular-Kidney-Metabolic Programming.

Tain Y, Hsu C Int J Mol Sci. 2024; 25(9).

PMID: 38731818 PMC: 11083012. DOI: 10.3390/ijms25094599.

The Impact of Nutrient Intake and Metabolic Wastes during Pregnancy on Offspring Hypertension: Challenges and Future Opportunities.

Tain Y, Hsu C Metabolites. 2023; 13(3).

PMID: 36984857 PMC: 10052993. DOI: 10.3390/metabo13030418.

Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress.

Tain Y, Hsu C Antioxidants (Basel). 2022; 11(11).

PMID: 36358480 PMC: 9686950. DOI: 10.3390/antiox11112108.

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