Effects of Maternal Resveratrol Intake on the Metabolic Health of the Offspring

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 May 5

PMID 33946456

Citations 2

Authors

Purificacion Ros

Jesus Argente

Julie A Chowen

Affiliations

Soon will be listed here.

Abstract

Maternal nutritional imbalances, in addition to maternal overweight and obesity, can result in long-term effects on the metabolic health of the offspring, increasing the risk of common non-communicable disorders such as obesity, diabetes and cardiovascular disease. This increased disease risk may also be transmitted across generations. Unfortunately, lifestyle interventions have shown reduced compliancy and limited efficacy. Resveratrol is a natural polyphenolic compound reported to have pleiotropic beneficial actions including a possible protective effect against the metabolic programming induced by poor dietary habits during development. However, studies to date are inconclusive regarding the potential metabolic benefits of maternal resveratrol supplementation during pregnancy and lactation on the offspring. Moreover, the responses to metabolic challenges are suggested to be different in males and females, suggesting that the effectiveness of treatment strategies may also differ, but many studies have been performed only in males. Here we review the current evidence, both in humans and animal models, regarding the possible beneficial effects of maternal resveratrol intake on the metabolic health of the offspring and highlight the different effects of resveratrol depending on the maternal diet, as well as the differential responses of males and females.

Citing Articles

Maternal lipids in overweight and obesity: implications for pregnancy outcomes and offspring's body composition.

Albrecht M, Worthmann A, Heeren J, Diemert A, Arck P Semin Immunopathol. 2025; 47(1):10.

PMID: 39841244 PMC: 11754334. DOI: 10.1007/s00281-024-01033-6.

Early Life Programming of Adipose Tissue Remodeling and Browning Capacity by Micronutrients and Bioactive Compounds as a Potential Anti-Obesity Strategy.

Bonet M, Ribot J, Sanchez J, Palou A, Pico C Cells. 2024; 13(10.

PMID: 38786092 PMC: 11120104. DOI: 10.3390/cells13100870.

Resveratrol Supplementation in Obese Pregnant Rats Improves Maternal Metabolism and Prevents Increased Placental Oxidative Stress.

Rodriguez-Gonzalez G, Vargas-Hernandez L, Reyes-Castro L, Ibanez C, Bautista C, Lomas-Soria C Antioxidants (Basel). 2022; 11(10).

PMID: 36290594 PMC: 9598144. DOI: 10.3390/antiox11101871.

References

Roberts V, Pound L, Thorn S, Gillingham M, Thornburg K, Friedman J . Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates. FASEB J. 2014; 28(6):2466-77. PMC: 4021444. DOI: 10.1096/fj.13-245472. View

Meng T, Xiao D, Muhammed A, Deng J, Chen L, He J . Anti-Inflammatory Action and Mechanisms of Resveratrol. Molecules. 2021; 26(1). PMC: 7796143. DOI: 10.3390/molecules26010229. View

Fuchs J, Hovorka R . Closed-loop control in insulin pumps for type-1 diabetes mellitus: safety and efficacy. Expert Rev Med Devices. 2020; 17(7):707-720. PMC: 7441745. DOI: 10.1080/17434440.2020.1784724. View

Truong V, Jun M, Jeong W . Role of resveratrol in regulation of cellular defense systems against oxidative stress. Biofactors. 2017; 44(1):36-49. DOI: 10.1002/biof.1399. View

Liu W, Wu C, Fu M, Tain Y, Liang C, Hung C . Maternal high fructose-induced hippocampal neuroinflammation in the adult female offspring via PPARγ-NF-κB signaling. J Nutr Biochem. 2020; 81:108378. DOI: 10.1016/j.jnutbio.2020.108378. View

Hou C, Tain Y, Yu H, Huang L . The Effects of Resveratrol in the Treatment of Metabolic Syndrome. Int J Mol Sci. 2019; 20(3). PMC: 6387422. DOI: 10.3390/ijms20030535. View

Roseboom T . Epidemiological evidence for the developmental origins of health and disease: effects of prenatal undernutrition in humans. J Endocrinol. 2019; 242(1):T135-T144. DOI: 10.1530/JOE-18-0683. View

Argente-Arizon P, Ros P, Diaz F, Fuente-Martin E, Castro-Gonzalez D, Sanchez-Garrido M . Age and sex dependent effects of early overnutrition on metabolic parameters and the role of neonatal androgens. Biol Sex Differ. 2016; 7:26. PMC: 4870809. DOI: 10.1186/s13293-016-0079-5. View

Martel J, Ojcius D, Chang C, Lin C, Lu C, Ko Y . Anti-obesogenic and antidiabetic effects of plants and mushrooms. Nat Rev Endocrinol. 2016; 13(3):149-160. DOI: 10.1038/nrendo.2016.142. View

10.

Koletzko B, Godfrey K, Poston L, Szajewska H, van Goudoever J, de Waard M . Nutrition During Pregnancy, Lactation and Early Childhood and its Implications for Maternal and Long-Term Child Health: The Early Nutrition Project Recommendations. Ann Nutr Metab. 2019; 74(2):93-106. PMC: 6397768. DOI: 10.1159/000496471. View

11.

Barker D . Obesity and early life. Obes Rev. 2007; 8 Suppl 1:45-9. DOI: 10.1111/j.1467-789X.2007.00317.x. View

12.

Clancy B, Finlay B, Darlington R, Anand K . Extrapolating brain development from experimental species to humans. Neurotoxicology. 2007; 28(5):931-7. PMC: 2077812. DOI: 10.1016/j.neuro.2007.01.014. View

13.

Tsai T, Tsai C, Huang L, Sheen J, Tiao M, Tain Y . Maternal Resveratrol Treatment Re-Programs and Maternal High-Fat Diet-Induced Retroperitoneal Adiposity in Male Offspring. Int J Environ Res Public Health. 2020; 17(8). PMC: 7215689. DOI: 10.3390/ijerph17082780. View

14.

Pound L, Comstock S, Grove K . Consumption of a Western-style diet during pregnancy impairs offspring islet vascularization in a Japanese macaque model. Am J Physiol Endocrinol Metab. 2014; 307(1):E115-23. PMC: 4080145. DOI: 10.1152/ajpendo.00131.2014. View

15.

Bayol S, Simbi B, Bertrand J, Stickland N . Offspring from mothers fed a 'junk food' diet in pregnancy and lactation exhibit exacerbated adiposity that is more pronounced in females. J Physiol. 2008; 586(13):3219-30. PMC: 2538787. DOI: 10.1113/jphysiol.2008.153817. View

16.

McMillen I, Robinson J . Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev. 2005; 85(2):571-633. DOI: 10.1152/physrev.00053.2003. View

17.

Eriksson J . Developmental Origins of Health and Disease - from a small body size at birth to epigenetics. Ann Med. 2016; 48(6):456-467. DOI: 10.1080/07853890.2016.1193786. View

18.

Tain Y, Hsu C . Developmental Programming of the Metabolic Syndrome: Can We Reprogram with Resveratrol?. Int J Mol Sci. 2018; 19(9). PMC: 6164855. DOI: 10.3390/ijms19092584. View

19.

Franco J, Dias-Rocha C, Fernandes T, Albuquerque Maia L, Lisboa P, Moura E . Resveratrol treatment rescues hyperleptinemia and improves hypothalamic leptin signaling programmed by maternal high-fat diet in rats. Eur J Nutr. 2015; 55(2):601-610. DOI: 10.1007/s00394-015-0880-7. View

20.

Breton C . The hypothalamus-adipose axis is a key target of developmental programming by maternal nutritional manipulation. J Endocrinol. 2012; 216(2):R19-31. DOI: 10.1530/JOE-12-0157. View