Early-Life Programming and Reprogramming of Adult Kidney Disease and Hypertension: The Interplay Between Maternal Nutrition and Oxidative Stress

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 May 24

PMID 32443635

Citations 17

Authors

Chien-Ning Hsu

You-Lin Tain

Affiliations

Soon will be listed here.

Abstract

Kidney disease and hypertension both have attained the status of a global pandemic. Altered renal programming resulting in kidney disease and hypertension can begin in utero. Maternal suboptimal nutrition and oxidative stress have important implications in renal programming, while specific antioxidant nutrient supplementations may serve as reprogramming strategies to prevent kidney disease and hypertension of developmental origins. This review aims to summarize current knowledge on the interplay of maternal nutrition and oxidative stress in response to early-life insults and its impact on developmental programming of kidney disease and hypertension, covering two aspects. Firstly, we present the evidence from animal models supporting the implication of oxidative stress on adult kidney disease and hypertension programmed by suboptimal maternal nutrition. In the second part, we document data on specific antioxidant nutrients as reprogramming strategies to protect adult offspring against kidney disease and hypertension from developmental origins. Research into the prevention of kidney disease and hypertension that begin early in life will have profound implications for future health.

Citing Articles

The Impact of Gestational Diabetes on Kidney Development: is There an Epigenetic Link?.

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Morphometric analysis of the intergenerational effects of protein restriction on nephron endowment in mice.

Diniz F, Edgington-Giordano F, Ngo N, Caspi G, El-Dahr S, Tortelote G Heliyon. 2024; 10(20):e39552.

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Maternal Polyphenols and Offspring Cardiovascular-Kidney-Metabolic Health.

Tain Y, Hsu C Nutrients. 2024; 16(18).

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The Beneficial Effects of Prenatal Biotin Supplementation in a Rat Model of Intrauterine Caloric Restriction to Prevent Cardiometabolic Risk in Adult Female Offspring.

Aguilera-Mendez A, Figueroa-Fierros I, Ruiz-Perez X, Godinez-Hernandez D, Saavedra-Molina A, Rios-Chavez P Int J Mol Sci. 2024; 25(16).

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Amino Acids during Pregnancy and Offspring Cardiovascular-Kidney-Metabolic Health.

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References

Chen T, Tian M, Han Y . Hydrogen sulfide: a multi-tasking signal molecule in the regulation of oxidative stress responses. J Exp Bot. 2020; 71(10):2862-2869. DOI: 10.1093/jxb/eraa093. View

Jackson A, Dunn R, Marchand M, Langley-Evans S . Increased systolic blood pressure in rats induced by a maternal low-protein diet is reversed by dietary supplementation with glycine. Clin Sci (Lond). 2002; 103(6):633-9. DOI: 10.1042/cs1030633. View

Goyal R, Van-Wickle J, Goyal D, Longo L . Antenatal maternal low protein diet: ACE-2 in the mouse lung and sexually dimorphic programming of hypertension. BMC Physiol. 2015; 15:2. PMC: 4430899. DOI: 10.1186/s12899-015-0016-6. View

Paixao A, Alexander B . How the kidney is impacted by the perinatal maternal environment to develop hypertension. Biol Reprod. 2013; 89(6):144. PMC: 4076357. DOI: 10.1095/biolreprod.113.111823. View

Tain Y, Hsieh C, Lin I, Chen C, Sheen J, Huang L . Effects of maternal L-citrulline supplementation on renal function and blood pressure in offspring exposed to maternal caloric restriction: the impact of nitric oxide pathway. Nitric Oxide. 2010; 23(1):34-41. DOI: 10.1016/j.niox.2010.03.005. View

Haider B, Bhutta Z . Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev. 2017; 4:CD004905. PMC: 6478115. DOI: 10.1002/14651858.CD004905.pub5. View

Hsu C, Tain Y . Hydrogen Sulfide in Hypertension and Kidney Disease of Developmental Origins. Int J Mol Sci. 2018; 19(5). PMC: 5983690. DOI: 10.3390/ijms19051438. View

Bertram J, Douglas-Denton R, Diouf B, Hughson M, Hoy W . Human nephron number: implications for health and disease. Pediatr Nephrol. 2011; 26(9):1529-33. DOI: 10.1007/s00467-011-1843-8. View

Remacle C, Bieswal F, Bol V, Reusens B . Developmental programming of adult obesity and cardiovascular disease in rodents by maternal nutrition imbalance. Am J Clin Nutr. 2011; 94(6 Suppl):1846S-1852S. DOI: 10.3945/ajcn.110.001651. View

10.

White S, Perkovic V, Cass A, Chang C, Poulter N, Spector T . Is low birth weight an antecedent of CKD in later life? A systematic review of observational studies. Am J Kidney Dis. 2009; 54(2):248-61. DOI: 10.1053/j.ajkd.2008.12.042. View

11.

Tain Y, Hsu C, Chan J, Huang L . Renal Transcriptome Analysis of Programmed Hypertension Induced by Maternal Nutritional Insults. Int J Mol Sci. 2015; 16(8):17826-37. PMC: 4581224. DOI: 10.3390/ijms160817826. View

12.

Resende A, Emiliano A, Cordeiro V, de Bem G, de Cavalho L, de Oliveira P . Grape skin extract protects against programmed changes in the adult rat offspring caused by maternal high-fat diet during lactation. J Nutr Biochem. 2013; 24(12):2119-26. DOI: 10.1016/j.jnutbio.2013.08.003. View

13.

Boubred F, Buffat C, Feuerstein J, Daniel L, Tsimaratos M, Oliver C . Effects of early postnatal hypernutrition on nephron number and long-term renal function and structure in rats. Am J Physiol Renal Physiol. 2007; 293(6):F1944-9. DOI: 10.1152/ajprenal.00141.2007. View

14.

Tain Y, Hsu C . Toxic Dimethylarginines: Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA). Toxins (Basel). 2017; 9(3). PMC: 5371847. DOI: 10.3390/toxins9030092. View

15.

Tain Y, Wu K, Lee W, Leu S, Chan J . Maternal fructose-intake-induced renal programming in adult male offspring. J Nutr Biochem. 2015; 26(6):642-50. DOI: 10.1016/j.jnutbio.2014.12.017. View

16.

Koleganova N, Piecha G, Ritz E, Becker L, Muller A, Weckbach M . Both high and low maternal salt intake in pregnancy alter kidney development in the offspring. Am J Physiol Renal Physiol. 2011; 301(2):F344-54. DOI: 10.1152/ajprenal.00626.2010. View

17.

Sengupta P . The Laboratory Rat: Relating Its Age With Human's. Int J Prev Med. 2013; 4(6):624-30. PMC: 3733029. View

18.

Schwarzenberg S, Georgieff M . Advocacy for Improving Nutrition in the First 1000 Days to Support Childhood Development and Adult Health. Pediatrics. 2018; 141(2). DOI: 10.1542/peds.2017-3716. View

19.

Sathishkumar K, Elkins R, Yallampalli U, Yallampalli C . Protein restriction during pregnancy induces hypertension and impairs endothelium-dependent vascular function in adult female offspring. J Vasc Res. 2008; 46(3):229-39. PMC: 2860528. DOI: 10.1159/000166390. View

20.

Vieira-Filho L, Cabral E, Farias J, Silva P, Muzi-Filho H, Vieyra A . Renal molecular mechanisms underlying altered Na+ handling and genesis of hypertension during adulthood in prenatally undernourished rats. Br J Nutr. 2014; 111(11):1932-44. DOI: 10.1017/S0007114513004236. View