Melanoma and Nuclear Medicine

Overview

Journal Melanoma Manag

Date 2018 Sep 8

PMID 30190811

Citations 4

Authors

Andres Perissinotti

Sergi Vidal-Sicart

Omgo Nieweg

Renato Valdes Olmos

Affiliations

Soon will be listed here.

Abstract

Supported by a large body of published work, the contribution of nuclear medicine technologies to the assessment of melanoma has been increasing in recent years. Lymphoscintigraphy-assisted sentinel lymph node biopsy and PET are in continuous evolution with the aid of technological imaging advances, making it possible to fuse functional and anatomic images (e.g., with SPECT/CT, PET/CT and 3D rendering systems). The development of hybrid fluorescent-radioactive tracers that enable high-quality preoperative lymphoscintigraphy and SPECT/CT, and the optimization of modern intraoperative portable imaging technologies, such as free-hand SPECT and portable γ-cameras, are important innovations that have improved sentinel lymph node identification in complex anatomical areas, such as the pelvis and head and neck. Concurrently, F-fluorodeoxyglucose-PET has proved its usefulness in the clinical staging and treatment decision-making process, and there is also emerging evidence regarding its utility in the evaluation of therapeutic response. The potential uses of other novel PET radiotracers could open up a new field of use for this technique. In this article, we review the current and future role of nuclear medicine in the management of melanoma.

Citing Articles

Primary malignant melanoma of the lung; a case report and literature review.

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Precision Oncology in Melanoma: Changing Practices.

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A SPECT/NIR Fluorescence Dual-Modality Imaging Agent Composed of Drugs and Hospital Available Isotope for Preoperative Sentinel Lymph Node Mapping and Intraoperative Biopsy.

Zhou M, Liu P, Yin X, Deng C, Xiao Y, Lei M Int J Nanomedicine. 2023; 18:7637-7646.

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[Case study of vulvar malignant melanoma conducted at the Cinquantenaire General Hospital in Lubumbashi].

Mukeya G, Kakoka I, Mwansa J, Kalau W Pan Afr Med J. 2020; 36:124.

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Melanoma & nuclear medicine: new insights & advances.

Perissinotti A, Rietbergen D, Vidal-Sicart S, Riera A, Olmos R Melanoma Manag. 2018; 5(1):MMT06.

PMID: 30190932 PMC: 6122522. DOI: 10.2217/mmt-2017-0022.

References

Vermeeren L, Meinhardt W, Bex A, van der Poel H, Vogel W, Hoefnagel C . Paraaortic sentinel lymph nodes: toward optimal detection and intraoperative localization using SPECT/CT and intraoperative real-time imaging. J Nucl Med. 2010; 51(3):376-82. DOI: 10.2967/jnumed.109.071779. View

van der Vorst J, Schaafsma B, Verbeek F, Swijnenburg R, Hutteman M, Liefers G . Dose optimization for near-infrared fluorescence sentinel lymph node mapping in patients with melanoma. Br J Dermatol. 2012; 168(1):93-8. PMC: 3607940. DOI: 10.1111/bjd.12059. View

Ortin-Perez J, Vidal-Sicart S, Domenech B, Rubi S, Lafuente S, Pons F . [In-transit sentinel lymph nodes in malignant melanoma. What is their importance?]. Rev Esp Med Nucl. 2008; 27(6):424-9. View

Povoski S, Neff R, Mojzisik C, OMalley D, Hinkle G, Hall N . A comprehensive overview of radioguided surgery using gamma detection probe technology. World J Surg Oncol. 2009; 7:11. PMC: 2653072. DOI: 10.1186/1477-7819-7-11. View

Rbah-Vidal L, Vidal A, Besse S, Cachin F, Bonnet M, Audin L . Early detection and longitudinal monitoring of experimental primary and disseminated melanoma using [¹⁰F]ICF01006, a highly promising melanoma PET tracer. Eur J Nucl Med Mol Imaging. 2012; 39(9):1449-61. DOI: 10.1007/s00259-012-2168-y. View

van der Ploeg I, Nieweg O, Kroon B, Rutgers E, Baas-Vrancken Peeters M, Vogel W . The yield of SPECT/CT for anatomical lymphatic mapping in patients with breast cancer. Eur J Nucl Med Mol Imaging. 2009; 36(6):903-9. DOI: 10.1007/s00259-008-1050-4. View

Testori A, De Salvo G, Montesco M, Trifiro G, Mocellin S, Landi G . Clinical considerations on sentinel node biopsy in melanoma from an Italian multicentric study on 1,313 patients (SOLISM-IMI). Ann Surg Oncol. 2009; 16(7):2018-27. DOI: 10.1245/s10434-008-0273-8. View

Perissinotti A, Paredes P, Vidal-Sicart S, Torne A, Albela S, Navales I . Use of SPECT/CT for improved sentinel lymph node localization in endometrial cancer. Gynecol Oncol. 2013; 129(1):42-8. DOI: 10.1016/j.ygyno.2013.01.022. View

Kruijff S, Bastiaannet E, Speijers M, Kobold A, Brouwers A, Hoekstra H . The value of pre operative S-100B and SUV in clinically stage III melanoma patients undergoing therapeutic lymph node dissection. Eur J Surg Oncol. 2011; 37(3):225-32. DOI: 10.1016/j.ejso.2010.12.013. View

10.

Nieweg O, Tanis P, Kroon B . The definition of a sentinel node. Ann Surg Oncol. 2001; 8(6):538-41. DOI: 10.1007/s10434-001-0538-y. View

11.

Khafif A, Schneebaum S, Fliss D, Lerman H, Metser U, Ben-Yosef R . Lymphoscintigraphy for sentinel node mapping using a hybrid single photon emission CT (SPECT)/CT system in oral cavity squamous cell carcinoma. Head Neck. 2006; 28(10):874-9. DOI: 10.1002/hed.20434. View

12.

Martinez A, Zerdoud S, Mery E, Bouissou E, Ferron G, Querleu D . Hybrid imaging by SPECT/CT for sentinel lymph node detection in patients with cancer of the uterine cervix. Gynecol Oncol. 2010; 119(3):431-5. DOI: 10.1016/j.ygyno.2010.08.001. View

13.

Estourgie S, Nieweg O, Olmos R, Hoefnagel C, Kroon B . Review and evaluation of sentinel node procedures in 250 melanoma patients with a median follow-up of 6 years. Ann Surg Oncol. 2003; 10(6):681-8. DOI: 10.1245/aso.2003.01.023. View

14.

Zaknun J, Giammarile F, Olmos R, Vidal-Sicart S, Mariani G . Changing paradigms in radioguided surgery and intraoperative imaging: the GOSTT concept. Eur J Nucl Med Mol Imaging. 2011; 39(1):1-3. DOI: 10.1007/s00259-011-1951-5. View

15.

Gajdos C, Griffith K, Wong S, Johnson T, Chang A, Cimmino V . Is there a benefit to sentinel lymph node biopsy in patients with T4 melanoma?. Cancer. 2009; 115(24):5752-60. DOI: 10.1002/cncr.24660. View

16.

van der Poel H, Buckle T, Brouwer O, Olmos R, van Leeuwen F . Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer. Eur Urol. 2011; 60(4):826-33. DOI: 10.1016/j.eururo.2011.03.024. View

17.

van Akkooi A, Voit C, Verhoef C, Eggermont A . New developments in sentinel node staging in melanoma: controversies and alternatives. Curr Opin Oncol. 2010; 22(3):169-77. DOI: 10.1097/CCO.0b013e328337aa78. View

18.

Wright B, Scheri R, Ye X, Faries M, Turner R, Essner R . Importance of sentinel lymph node biopsy in patients with thin melanoma. Arch Surg. 2008; 143(9):892-9. PMC: 2561951. DOI: 10.1001/archsurg.143.9.892. View

19.

Troyan S, Kianzad V, Gibbs-Strauss S, Gioux S, Matsui A, Oketokoun R . The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in breast cancer sentinel lymph node mapping. Ann Surg Oncol. 2009; 16(10):2943-52. PMC: 2772055. DOI: 10.1245/s10434-009-0594-2. View

20.

Vidal-Sicart S, Pons F, Fuertes S, Vilalta A, Rull R, Puig S . Is the identification of in-transit sentinel lymph nodes in malignant melanoma patients really necessary?. Eur J Nucl Med Mol Imaging. 2004; 31(7):945-9. DOI: 10.1007/s00259-004-1485-1. View