Lymphoscintigraphy for Sentinel Node Mapping Using a Hybrid Single Photon Emission CT (SPECT)/CT System in Oral Cavity Squamous Cell Carcinoma

Overview

Journal Head Neck

Specialties General Surgery
Oncology

Date 2006 Aug 26

PMID 16933311

Citations 31

Authors

Avi Khafif

Shlomo Schneebaum

Dan M Fliss

Hedva Lerman

U Metser

Rami Ben-Yosef

Ziv Gil

Leonor Reider-Trejo

Livshitz Genadi

Einat Even-Sapir

Affiliations

Soon will be listed here.

Abstract

Background: We assessed the added clinical value of fused single photon emission computed tomography (SPECT) and low-dose CT images compared with planar images for sentinel node (SN) mapping in patients with oral cavity squamous cell carcinoma (SCC).

Methods: Twenty consecutive patients with newly diagnosed biopsy-proven SCC of the oral cavity were enrolled. Scintigraphy was performed using a hybrid gamma-camera/low-dose CT system. Planar images and fused SPECT/CT images were interpreted separately. All patients underwent a sentinel node biopsy (SNB) followed by a neck dissection. All SNs underwent meticulous pathologic examination and immunohistochemistry staining (cytokeratin complex) in addition to routine pathologic examinations of the neck dissection specimen.

Results: The sensitivity for the detection of nodal metastases was 87.5%. SPECT/CT improved SN identification and/or localization compared with planar images in 6 patients (30%).

Conclusions: SPECT/CT SN mapping provides additional preoperative data of clinical relevance to SNB in patients with oral cavity SCC.

Citing Articles

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Advantages of Sentinel Lymph Node Mapping by Single Photon Emission Computed Tomography/Computed Tomography in Early-Stage Malignant Head-and-Neck Skin Tumors.

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Zanoni D, Stambuk H, Madajewski B, Montero P, Matsuura D, Busam K JAMA Netw Open. 2021; 4(3):e211936.

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Sugiyama S, Iwai T, Baba J, Oguri S, Izumi T, Sekino M Dentomaxillofac Radiol. 2020; 50(4):20200333.

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Hershenhouse K, Shauly O, Gould D, Patel K Neurosci Insights. 2020; 14:1179069519889027.

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