The Role of Interferon-Gamma in Hematopoietic Stem Cell Development, Homeostasis, and Disease

Overview

Journal Curr Stem Cell Rep

Date 2018 Aug 28

PMID 30148048

Citations 53

Authors

Daniel E Morales-Mantilla

Katherine Y King

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Interferon-gamma (IFN-γ) is a pro-inflammatory cytokine that participates in the regulation of hematopoietic stem cells (HSC) during development and under homeostatic conditions. IFN-γ also plays a key pathogenic role in several diseases that affect hematopoiesis including aplastic anemia, hemophagocytic lymphohistiocytosis, and cirrhosis of the liver.

Recent Findings: Studies have shown that increased IFN-γ negatively affects HSC homeostasis, skewing HSC towards differentiation over self-renewal and eventually causing exhaustion of the HSC compartment.

Summary: Here, we explore the mechanisms by which IFN-γ regulates HSC in both normal and pathological conditions. We focus on the role of IFN-γ signaling in HSC fate decisions, and the transcriptional changes it elicits. Elucidating the mechanisms through which IFN-γ regulates HSCs may lead to new therapeutic options to prevent or treat adverse hematologic effects of the many diseases to which IFN-γ contributes.

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