The Bone Marrow Stem Cell Niche Grows Up: Mesenchymal Stem Cells and Macrophages Move in

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2011 Mar 16

PMID 21402747

Citations 233

Authors

Armin Ehninger

Andreas Trumpp

Affiliations

Soon will be listed here.

Abstract

Stem cell niches are defined as the cellular and molecular microenvironments that regulate stem cell function together with stem cell autonomous mechanisms. This includes control of the balance between quiescence, self-renewal, and differentiation, as well as the engagement of specific programs in response to stress. In mammals, the best understood niche is that harboring bone marrow hematopoietic stem cells (HSCs). Recent studies have expanded the number of cell types contributing to the HSC niche. Perivascular mesenchymal stem cells and macrophages now join the previously identified sinusoidal endothelial cells, sympathetic nerve fibers, and cells of the osteoblastic lineage to form similar, but distinct, niches that harbor dormant and self-renewing HSCs during homeostasis and mediate stem cell mobilization in response to granulocyte colony-stimulating factor.

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