Expression of the Human C-fms Proto-oncogene Product (colony-stimulating Factor-1 Receptor) on Peripheral Blood Mononuclear Cells and Choriocarcinoma Cell Lines

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1986 Jun 1

PMID 3011859

Citations 29

Authors

C W Rettenmier

R Sacca

W L Furman

M F Roussel

J T Holt

A W Nienhuis

E R Stanley

C J Sherr

Affiliations

Soon will be listed here.

Abstract

The c-fms gene product is related, and possibly identical, to the receptor for the mononuclear phagocyte colony stimulating factor, CSF-1. Using antisera to a recombinant v-fms--coded polypeptide, glycoproteins encoded by the human c-fms locus were detected in mononuclear cells from normal peripheral blood and in promyelocytic HL-60 cells 24 h after induction of monocytic differentiation with phorbol ester. The 150-kD human c-fms--coded glycoprotein was expressed at the cell surface, was active as a tyrosine-specific protein kinase in vitro, and shared primary structural features with the product of the feline retroviral v-fms oncogene. A biochemically indistinguishable glycoprotein was detected in human choriocarcinoma cell lines. Like peripheral blood mononuclear cells and phorbol ester-treated HL-60 cells, the choriocarcinoma cells expressed high affinity binding sites for human CSF-1. In addition to serving as a lineage specific growth factor in hematopoiesis, CSF-1 may play a role in normal trophoblast development.

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References

Chen B, Lin H, Hsu S . Tumor-promoting phorbol esters inhibit the binding of colony-stimulating factor (CSF-1) to murine peritoneal exudate macrophages. J Cell Physiol. 1983; 116(2):207-12. DOI: 10.1002/jcp.1041160212. View

Tushinski R, Oliver I, Guilbert L, Tynan P, Warner J, Stanley E . Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy. Cell. 1982; 28(1):71-81. DOI: 10.1016/0092-8674(82)90376-2. View

Muller R, TREMBLAY J, Adamson E, Verma I . Tissue and cell type-specific expression of two human c-onc genes. Nature. 1983; 304(5925):454-6. DOI: 10.1038/304454a0. View

Stanley E, Guilbert L, Tushinski R, Bartelmez S . CSF-1--a mononuclear phagocyte lineage-specific hemopoietic growth factor. J Cell Biochem. 1983; 21(2):151-9. DOI: 10.1002/jcb.240210206. View

Morgan C, Stanley E . Chemical crosslinking of the mononuclear phagocyte specific growth factor CSF-1 to its receptor at the cell surface. Biochem Biophys Res Commun. 1984; 119(1):35-41. DOI: 10.1016/0006-291x(84)91614-0. View

Slamon D, DeKernion J, Verma I, Cline M . Expression of cellular oncogenes in human malignancies. Science. 1984; 224(4646):256-62. DOI: 10.1126/science.6538699. View

Anderson S, Gonda M, Rettenmier C, Sherr C . Subcellular localization of glycoproteins encoded by the viral oncogene v-fms. J Virol. 1984; 51(3):730-41. PMC: 255838. DOI: 10.1128/JVI.51.3.730-741.1984. View

Manger R, Najita L, Nichols E, Hakomori S, Rohrschneider L . Cell surface expression of the McDonough strain of feline sarcoma virus fms gene product (gp 140fms). Cell. 1984; 39(2 Pt 1):327-37. DOI: 10.1016/0092-8674(84)90011-4. View

Roussel M, Rettenmier C, Look A, Sherr C . Cell surface expression of v-fms-coded glycoproteins is required for transformation. Mol Cell Biol. 1984; 4(10):1999-2009. PMC: 369016. DOI: 10.1128/mcb.4.10.1999-2009.1984. View

10.

Bartelmez S, Stanley E . Synergism between hemopoietic growth factors (HGFs) detected by their effects on cells bearing receptors for a lineage specific HGF: assay of hemopoietin-1. J Cell Physiol. 1985; 122(3):370-8. DOI: 10.1002/jcp.1041220306. View

11.

Rettenmier C, Chen J, Roussel M, Sherr C . The product of the c-fms proto-oncogene: a glycoprotein with associated tyrosine kinase activity. Science. 1985; 228(4697):320-2. DOI: 10.1126/science.2580348. View

12.

Rettenmier C, Roussel M, Quinn C, Kitchingman G, Look A, Sherr C . Transmembrane orientation of glycoproteins encoded by the v-fms oncogene. Cell. 1985; 40(4):971-81. DOI: 10.1016/0092-8674(85)90357-5. View

13.

Sherr C, Rettenmier C, Sacca R, Roussel M, Look A, Stanley E . The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. Cell. 1985; 41(3):665-76. DOI: 10.1016/s0092-8674(85)80047-7. View

14.

Sariban E, Mitchell T, Kufe D . Expression of the c-fms proto-oncogene during human monocytic differentiation. Nature. 1985; 316(6023):64-6. DOI: 10.1038/316064a0. View

15.

Nienhuis A, BUNN H, Turner P, Gopal T, Nash W, OBrien S . Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q- syndrome. Cell. 1985; 42(2):421-8. DOI: 10.1016/0092-8674(85)90099-6. View

16.

Kawasaki E, Ladner M, Wang A, Van Arsdell J, Warren M, Coyne M . Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1). Science. 1985; 230(4723):291-6. DOI: 10.1126/science.2996129. View

17.

Guilbert L, Stanley E . The interaction of 125I-colony-stimulating factor-1 with bone marrow-derived macrophages. J Biol Chem. 1986; 261(9):4024-32. View

18.

Coussens L, Van Beveren C, Smith D, Chen E, Mitchell R, Isacke C . Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus. Nature. 1986; 320(6059):277-80. DOI: 10.1038/320277a0. View

19.

Woolford J, Rothwell V, Rohrschneider L . Characterization of the human c-fms gene product and its expression in cells of the monocyte-macrophage lineage. Mol Cell Biol. 1985; 5(12):3458-66. PMC: 369176. DOI: 10.1128/mcb.5.12.3458-3466.1985. View

20.

DILLARD G, BRECHER G, CRONKITE E . Separation, concentration, and transfusion of platelets. Proc Soc Exp Biol Med. 1951; 78(3):796-9. DOI: 10.3181/00379727-78-19223. View