Keep Moving and Stay in a Good Shape to Find Your Homologous Recombination Partner

Overview

Journal Curr Genet

Specialty Genetics

Date 2018 Aug 12

PMID 30097675

Citations 21

Authors

Helene Bordelet

Karine Dubrana

Affiliations

Soon will be listed here.

Abstract

Genomic DNA is constantly exposed to damage. Among the lesion in DNA, double-strand breaks (DSB), because they disrupt the two strands of the DNA double helix, are the more dangerous. DSB are repaired through two evolutionary conserved mechanisms: Non-Homologous End Joining (NHEJ) and Homologous Recombination (HR). Whereas NHEJ simply reseals the double helix with no or minimal processing, HR necessitates the formation of a 3'ssDNA through the processing of DSB ends by the resection machinery and relies on the recognition and pairing of this 3'ssDNA tails with an intact homologous sequence. Despite years of active research on HR, the manner by which the two homologous sequences find each other in the crowded nucleus, and how this modulates HR efficiency, only recently emerges. Here, we review recent advances in our understanding of the factors limiting the search of a homologous sequence during HR.

Citing Articles

Cohesin complex oligomerization maintains end-tethering at DNA double-strand breaks.

Phipps J, Toulouze M, Ducrot C, Costa R, Brocas C, Dubrana K Nat Cell Biol. 2024; 27(1):118-129.

PMID: 39482358 PMC: 11735392. DOI: 10.1038/s41556-024-01552-2.

Double-strand breaks in facultative heterochromatin require specific movements and chromatin changes for efficient repair.

Wensveen M, Dixit A, van Schendel R, Kendek A, Lambooij J, Tijsterman M Nat Commun. 2024; 15(1):8984.

PMID: 39419979 PMC: 11487122. DOI: 10.1038/s41467-024-53313-2.

Chromosome compartmentalization: causes, changes, consequences, and conundrums.

Li H, Playter C, Das P, McCord R Trends Cell Biol. 2024; 34(9):707-727.

PMID: 38395734 PMC: 11339242. DOI: 10.1016/j.tcb.2024.01.009.

All who wander are not lost: the search for homology during homologous recombination.

Hu J, Crickard J Biochem Soc Trans. 2024; 52(1):367-377.

PMID: 38323621 PMC: 10903458. DOI: 10.1042/BST20230705.

Liquid-liquid phase separation in DNA double-strand breaks repair.

Wang Y, Zhao W, Shi J, Wan X, Zheng J, Fan X Cell Death Dis. 2023; 14(11):746.

PMID: 37968256 PMC: 10651886. DOI: 10.1038/s41419-023-06267-0.

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