Mutation and Epistasis in Influenza Virus Evolution

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2018 Aug 8

PMID 30081492

Citations 53

Authors

Daniel M Lyons

Adam S Lauring

Affiliations

Soon will be listed here.

Abstract

Influenza remains a persistent public health challenge, because the rapid evolution of influenza viruses has led to marginal vaccine efficacy, antiviral resistance, and the annual emergence of novel strains. This evolvability is driven, in part, by the virus's capacity to generate diversity through mutation and reassortment. Because many new traits require multiple mutations and mutations are frequently combined by reassortment, epistatic interactions between mutations play an important role in influenza virus evolution. While mutation and epistasis are fundamental to the adaptability of influenza viruses, they also constrain the evolutionary process in important ways. Here, we review recent work on mutational effects and epistasis in influenza viruses.

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