The Persistent Legacy of the 1918 Influenza Virus

Overview

Journal N Engl J Med

Specialty General Medicine

Date 2009 Jul 1

PMID 19564629

Citations 158

Authors

David M Morens

Jeffery K Taubenberger

Anthony S Fauci

Affiliations

Soon will be listed here.

Citing Articles

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References

Dawood F, Jain S, Finelli L, Shaw M, Lindstrom S, Garten R . Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med. 2009; 360(25):2605-15. DOI: 10.1056/NEJMoa0903810. View

Dugan V, Chen R, Spiro D, Sengamalay N, Zaborsky J, Ghedin E . The evolutionary genetics and emergence of avian influenza viruses in wild birds. PLoS Pathog. 2008; 4(5):e1000076. PMC: 2387073. DOI: 10.1371/journal.ppat.1000076. View

Wang R, Soll L, Dugan V, Runstadler J, Happ G, Slemons R . Examining the hemagglutinin subtype diversity among wild duck-origin influenza A viruses using ethanol-fixed cloacal swabs and a novel RT-PCR method. Virology. 2008; 375(1):182-9. PMC: 2397557. DOI: 10.1016/j.virol.2008.01.041. View

Kilbourne E, Smith C, Brett I, Pokorny B, Johansson B, Cox N . The total influenza vaccine failure of 1947 revisited: major intrasubtypic antigenic change can explain failure of vaccine in a post-World War II epidemic. Proc Natl Acad Sci U S A. 2002; 99(16):10748-52. PMC: 125033. DOI: 10.1073/pnas.162366899. View

Garten R, Davis C, Russell C, Shu B, Lindstrom S, Balish A . Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science. 2009; 325(5937):197-201. PMC: 3250984. DOI: 10.1126/science.1176225. View

Pappas C, Aguilar P, Basler C, Solorzano A, Zeng H, Perrone L . Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus. Proc Natl Acad Sci U S A. 2008; 105(8):3064-9. PMC: 2268585. DOI: 10.1073/pnas.0711815105. View

Reid A, Taubenberger J, Fanning T . Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus. Nat Rev Microbiol. 2004; 2(11):909-14. PMC: 7097663. DOI: 10.1038/nrmicro1027. View

Holmes E, Ghedin E, Miller N, Taylor J, Bao Y, St George K . Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 viruses. PLoS Biol. 2005; 3(9):e300. PMC: 1180517. DOI: 10.1371/journal.pbio.0030300. View

Kash J, Tumpey T, Proll S, Carter V, Perwitasari O, Thomas M . Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature. 2006; 443(7111):578-81. PMC: 2615558. DOI: 10.1038/nature05181. View

10.

Thompson W, Shay D, Weintraub E, Brammer L, Cox N, Anderson L . Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA. 2003; 289(2):179-86. DOI: 10.1001/jama.289.2.179. View

11.

Taubenberger J, Reid A, Lourens R, Wang R, Jin G, Fanning T . Characterization of the 1918 influenza virus polymerase genes. Nature. 2005; 437(7060):889-93. DOI: 10.1038/nature04230. View

12.

Foppa I, Hossain M . Revised estimates of influenza-associated excess mortality, United States, 1995 through 2005. Emerg Themes Epidemiol. 2009; 5:26. PMC: 2628891. DOI: 10.1186/1742-7622-5-26. View

13.

Simonsen L, Clarke M, Stroup D, Williamson G, Arden N, Cox N . A method for timely assessment of influenza-associated mortality in the United States. Epidemiology. 1997; 8(4):390-5. DOI: 10.1097/00001648-199707000-00007. View

14.

Rambaut A, Pybus O, Nelson M, Viboud C, Taubenberger J, Holmes E . The genomic and epidemiological dynamics of human influenza A virus. Nature. 2008; 453(7195):615-9. PMC: 2441973. DOI: 10.1038/nature06945. View

15.

Taubenberger J, Morens D . Pandemic influenza--including a risk assessment of H5N1. Rev Sci Tech. 2009; 28(1):187-202. PMC: 2720801. DOI: 10.20506/rst.28.1.1879. View

16.

Collins S, Lehmann J . Excess deaths from influenza and pneumonia and from important chronic diseases during epidemic periods, 1918-51. Public Health Monogr. 1953; 10:1-21. View

17.

Wolf Y, Viboud C, Holmes E, Koonin E, Lipman D . Long intervals of stasis punctuated by bursts of positive selection in the seasonal evolution of influenza A virus. Biol Direct. 2006; 1:34. PMC: 1647279. DOI: 10.1186/1745-6150-1-34. View

18.

Taubenberger J, Morens D . 1918 Influenza: the mother of all pandemics. Emerg Infect Dis. 2006; 12(1):15-22. PMC: 3291398. DOI: 10.3201/eid1201.050979. View

19.

Nelson M, Viboud C, Simonsen L, Bennett R, Griesemer S, St George K . Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918. PLoS Pathog. 2008; 4(2):e1000012. PMC: 2262849. DOI: 10.1371/journal.ppat.1000012. View

20.

Memoli M, Jagger B, Dugan V, Qi L, Jackson J, Taubenberger J . Recent human influenza A/H3N2 virus evolution driven by novel selection factors in addition to antigenic drift. J Infect Dis. 2009; 200(8):1232-41. PMC: 2778484. DOI: 10.1086/605893. View