Quinolones: Pharmacology

Overview

Journal Pharm Weekbl Sci

Specialty Pharmacy

Date 1986 Feb 21

PMID 3008075

Citations 3

Authors

L Verbist

Affiliations

Soon will be listed here.

Abstract

The quinolones are synthetic antibiotics chemically related to nalidixic acid. Since its introduction, several structural analogues have been synthesized. A fundamental breakthrough was the addition of a fluorine atom. The quinolones interfere with bacterial DNA transcription by inhibiting the enzyme DNA gyrase, that so far has only been found in bacteria. The nature of the activity of the quinolones on DNA gyrase makes it highly unlikely that resistance is carried on plasmids.

Citing Articles

In vitro activity and mode of action of fluoroquinolones.

Verbist L Pharm Weekbl Sci. 1987; 9 Suppl:S2-10.

PMID: 3438148 DOI: 10.1007/BF02075251.

Enoxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Henwood J, Monk J Drugs. 1988; 36(1):32-66.

PMID: 3063494 DOI: 10.2165/00003495-198836010-00004.

Structure-activity relationships of the fluoroquinolones.

Chu D, Fernandes P Antimicrob Agents Chemother. 1989; 33(2):131-5.

PMID: 2655528 PMC: 171443. DOI: 10.1128/AAC.33.2.131.

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