Red Blood Cell-hitchhiking Boosts Delivery of Nanocarriers to Chosen Organs by Orders of Magnitude

Overview

Journal Nat Commun

Specialty Biology

Date 2018 Jul 12

PMID 29992966

Citations 136

Authors

Jacob S Brenner

Daniel C Pan

Jacob W Myerson

Oscar A Marcos-Contreras

Carlos H Villa

Priyal Patel

Hugh Hekierski

Shampa Chatterjee

Jian-Qin Tao

Hamideh Parhiz

Kartik Bhamidipati

Thomas G Uhler

Elizabeth D Hood

Raisa Yu Kiseleva

Vladimir S Shuvaev

Tea Shuvaeva

Makan Khoshnejad

Ian Johnston

Jason V Gregory

Joerg Lahann

Tao Wang

Edward Cantu

William M Armstead

Samir Mitragotri

Vladimir Muzykantov

Affiliations

Soon will be listed here.

Abstract

Drug delivery by nanocarriers (NCs) has long been stymied by dominant liver uptake and limited target organ deposition, even when NCs are targeted using affinity moieties. Here we report a universal solution: red blood cell (RBC)-hitchhiking (RH), in which NCs adsorbed onto the RBCs transfer from RBCs to the first organ downstream of the intravascular injection. RH improves delivery for a wide range of NCs and even viral vectors. For example, RH injected intravenously increases liposome uptake in the first downstream organ, lungs, by ~40-fold compared with free NCs. Intra-carotid artery injection of RH NCs delivers >10% of the injected NC dose to the brain, ~10× higher than that achieved with affinity moieties. Further, RH works in mice, pigs, and ex vivo human lungs without causing RBC or end-organ toxicities. Thus, RH is a clinically translatable platform technology poised to augment drug delivery in acute lung disease, stroke, and several other diseases.

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