Does Adding Silver Nanoparticles to Leukocyte- and Platelet-Rich Fibrin Improve Its Properties?

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2018 Jul 7

PMID 29977918

Citations 11

Authors

Hooman Khorshidi

Pardis Haddadi

Saeed Raoofi

Parisa Badiee

Ali Dehghani Nazhvani

Affiliations

Soon will be listed here.

Abstract

Objectives: Leucocyte- and platelet-rich fibrin (L-PRF) membrane can be used in various regenerative treatments. In the case of classical heterologous membrane exposure, microorganisms can be colonized on it and jeopardize the success of treatment. The aim of this study was to compare the antibacterial, mechanical, and histologic characteristics of the L-PRF membrane before and after the addition of silver nanoparticles (SNP).

Materials And Method: This study was performed on 10 volunteer men aged 25-35 years. 20 ml whole bloods were collected from each person and L-PRFs were made by routine and SNP modified method. Mechanical, antibacterial, and histological properties were evaluated.

Results: The antibacterial efficacy of L-PRF and nanosilver-modified L-PRF was presented as had growth on the L-PRF membrane after 12 hours. After 24 hours, and had growth on L-PRF and only had growth on SNP-L-PRF. The tensile strength and stiffness were significantly higher in the SNP-L-PRF. Precipitation of the SNPs was patchy in the outer layers and quite homogeneous in the inner core.

Conclusion: Modification of L-PRF with SNP improves the mechanical properties and antibacterial activity of the L-PRF. It can play an important role in regenerative procedures.

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