Surgical Approaches Based on Biological Objectives: GTR Versus GBR Techniques

Overview

Journal Int J Dent

Publisher Wiley

Specialty Dentistry

Date 2013 Jul 12

PMID 23843792

Citations 16

Authors

Gaia Pellegrini

Giorgio Pagni

Giulio Rasperini

Affiliations

Soon will be listed here.

Abstract

Guided tissue regenerative (GTR) therapies are performed to regenerate the previously lost tooth supporting structure, thus maintaining the aesthetics and masticatory function of the available dentition. Alveolar ridge augmentation procedures (GBR) intend to regain the alveolar bone lost following tooth extraction and/or periodontal disease. Several biomaterials and surgical approaches have been proposed. In this paper we report biomaterials and surgical techniques used for periodontal and bone regenerative procedures. Particular attention will be adopted to highlight the biological basis for the different therapeutic approaches.

Citing Articles

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Development of Novel Polysaccharide Membranes for Guided Bone Regeneration: In Vitro and In Vivo Evaluations.

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Use of a Lateral Sinus Bony Window as an Intraoral Donor Site for Guided Bone Regeneration in Wide Post-Extraction Defects.

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References

Sculean A, Nikolidakis D, Schwarz F . Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials - biological foundation and preclinical evidence: a systematic review. J Clin Periodontol. 2008; 35(8 Suppl):106-16. DOI: 10.1111/j.1600-051X.2008.01263.x. View

Anitua E . The use of plasma-rich growth factors (PRGF) in oral surgery. Pract Proced Aesthet Dent. 2001; 13(6):487-93; quiz 487-93. View

Murakami S, Takayama S, Ikezawa K, Shimabukuro Y, Kitamura M, Nozaki T . Regeneration of periodontal tissues by basic fibroblast growth factor. J Periodontal Res. 2000; 34(7):425-30. DOI: 10.1111/j.1600-0765.1999.tb02277.x. View

Trombelli L, Simonelli A, Pramstraller M, Wikesjo U, Farina R . Single flap approach with and without guided tissue regeneration and a hydroxyapatite biomaterial in the management of intraosseous periodontal defects. J Periodontol. 2010; 81(9):1256-63. DOI: 10.1902/jop.2010.100113. View

Mordenfeld A, Hallman M, Johansson C, Albrektsson T . Histological and histomorphometrical analyses of biopsies harvested 11 years after maxillary sinus floor augmentation with deproteinized bovine and autogenous bone. Clin Oral Implants Res. 2010; 21(9):961-70. DOI: 10.1111/j.1600-0501.2010.01939.x. View

Pilloni A, Paolantonio M, Camargo P . Root coverage with a coronally positioned flap used in combination with enamel matrix derivative: 18-month clinical evaluation. J Periodontol. 2007; 77(12):2031-9. DOI: 10.1902/jop.2006.050390. View

Garcia-Godoy F, Murray P . Status and potential commercial impact of stem cell-based treatments on dental and craniofacial regeneration. Stem Cells Dev. 2007; 15(6):881-7. DOI: 10.1089/scd.2006.15.881. View

Pretzl B, Kim T, Holle R, Eickholz P . Long-term results of guided tissue regeneration therapy with non-resorbable and bioabsorbable barriers. IV. A case series of infrabony defects after 10 years. J Periodontol. 2008; 79(8):1491-9. DOI: 10.1902/jop.2008.070571. View

Heijl L . Periodontal regeneration with enamel matrix derivative in one human experimental defect. A case report. J Clin Periodontol. 1997; 24(9 Pt 2):693-6. DOI: 10.1034/j.1600-051x.1997.00693.x. View

10.

Nevins M, Kao R, McGuire M, McClain P, Hinrichs J, McAllister B . Platelet-derived growth factor promotes periodontal regeneration in localized osseous defects: 36-month extension results from a randomized, controlled, double-masked clinical trial. J Periodontol. 2012; 84(4):456-64. PMC: 5715458. DOI: 10.1902/jop.2012.120141. View

11.

Byun H, Wang H . Sandwich bone augmentation using recombinant human platelet-derived growth factor and beta-tricalcium phosphate alloplast: case report. Int J Periodontics Restorative Dent. 2008; 28(1):83-7. View

12.

Gamal A, Iacono V . Enhancing guided tissue regeneration of periodontal defects by using a novel perforated barrier membrane. J Periodontol. 2012; 84(7):905-13. DOI: 10.1902/jop.2012.120301. View

13.

Cortellini P, Prato G, Tonetti M . The simplified papilla preservation flap. A novel surgical approach for the management of soft tissues in regenerative procedures. Int J Periodontics Restorative Dent. 2000; 19(6):589-99. View

14.

Liu D, Xu J, Liu O, Fan Z, Liu Y, Wang F . Mesenchymal stem cells derived from inflamed periodontal ligaments exhibit impaired immunomodulation. J Clin Periodontol. 2012; 39(12):1174-82. DOI: 10.1111/jcpe.12009. View

15.

Esposito M, Grusovin M, Felice P, Karatzopoulos G, Worthington H, Coulthard P . The efficacy of horizontal and vertical bone augmentation procedures for dental implants - a Cochrane systematic review. Eur J Oral Implantol. 2010; 2(3):167-84. View

16.

Friedmann A, Strietzel F, Maretzki B, Pitaru S, Bernimoulin J . Histological assessment of augmented jaw bone utilizing a new collagen barrier membrane compared to a standard barrier membrane to protect a granular bone substitute material. Clin Oral Implants Res. 2003; 13(6):587-94. DOI: 10.1034/j.1600-0501.2002.130603.x. View

17.

Lekic P, Rajshankar D, Chen H, Tenenbaum H, McCulloch C . Transplantation of labeled periodontal ligament cells promotes regeneration of alveolar bone. Anat Rec. 2001; 262(2):193-202. DOI: 10.1002/1097-0185(20010201)262:2<193::AID-AR1028>3.0.CO;2-7. View

18.

Anitua E . Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants. 1999; 14(4):529-35. View

19.

Gkranias N, Graziani F, Sculean A, Donos N . Wound healing following regenerative procedures in furcation degree III defects: histomorphometric outcomes. Clin Oral Investig. 2010; 16(1):239-49. DOI: 10.1007/s00784-010-0478-7. View

20.

Chen F, Shelton R, Jin Y, Chapple I . Localized delivery of growth factors for periodontal tissue regeneration: role, strategies, and perspectives. Med Res Rev. 2009; 29(3):472-513. DOI: 10.1002/med.20144. View