Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2018 Jun 30

PMID 29955232

Citations 17

Authors

Qiwen Li

Yunshu Wu

Ning Kang

Affiliations

Soon will be listed here.

Abstract

Marrow adipose tissue (MAT) is a unique fat depot in the bone marrow and exhibits close relationship with hematopoiesis and bone homeostasis. MAT is distinct from peripheral adipose tissue in respect of its heterogeneous origin, site-specific distribution, and complex and perplexing function. Though MAT is indicated to function in hematopoiesis, skeletal remodeling, and energy metabolism, its explicit characterization still requires further research. In this review, we highlight recent advancement made in MAT regarding the origin and distribution of MAT, the local interaction with bone homeostasis and hematopoietic niche, the systemic endocrine regulation of metabolism, and MAT-based strategies to enhance bone formation.

Citing Articles

Potential probiotic Lactobacillus delbrueckii subsp. lactis KUMS-Y33 suppresses adipogenesis and promotes osteogenesis in human adipose-derived mesenchymal stem cell.

Goudarzi F, Kiani A, Nami Y, Shahmohammadi A, Mohammadalipour A, Karami A Sci Rep. 2024; 14(1):9689.

PMID: 38678043 PMC: 11055903. DOI: 10.1038/s41598-024-60061-2.

Bone marrow adipocytes and lung cancer bone metastasis: unraveling the role of adipokines in the tumor microenvironment.

Li J, Wu J, Xie Y, Yu X Front Oncol. 2024; 14:1360471.

PMID: 38571500 PMC: 10987778. DOI: 10.3389/fonc.2024.1360471.

Juvenile zebrafish (Danio rerio) are able to recover from lordosis.

Printzi A, Mazurais D, Witten P, Madec L, Gonzalez A, Mialhe X Sci Rep. 2022; 12(1):21533.

PMID: 36513797 PMC: 9748118. DOI: 10.1038/s41598-022-26112-2.

Insights into skeletal stem cells.

Li Q, Xu R, Lei K, Yuan Q Bone Res. 2022; 10(1):61.

PMID: 36261411 PMC: 9581935. DOI: 10.1038/s41413-022-00235-8.

Differential Blood Counts Do Not Consistently Predict Clinical Measurements of Bone Mineral Density and Microarchitecture at Homeostasis.

Schyrr F, Marques-Vidal P, Hans D, Lamy O, Naveiras O JBMR Plus. 2022; 6(9):e10669.

PMID: 36111204 PMC: 9464992. DOI: 10.1002/jbm4.10669.

References

Slade J, Coe L, Meyer R, McCabe L . Human bone marrow adiposity is linked with serum lipid levels not T1-diabetes. J Diabetes Complications. 2012; 26(1):1-9. DOI: 10.1016/j.jdiacomp.2011.11.001. View

Lecka-Czernik B, Baroi S, Stechschulte L, Chougule A . Marrow Fat-a New Target to Treat Bone Diseases?. Curr Osteoporos Rep. 2018; 16(2):123-129. DOI: 10.1007/s11914-018-0426-z. View

Yu L, Tu Q, Han Q, Zhang L, Sui L, Zheng L . Adiponectin regulates bone marrow mesenchymal stem cell niche through a unique signal transduction pathway: an approach for treating bone disease in diabetes. Stem Cells. 2014; 33(1):240-52. PMC: 4681406. DOI: 10.1002/stem.1844. View

Elbaz A, Wu X, Rivas D, Gimble J, Duque G . Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro. J Cell Mol Med. 2009; 14(4):982-91. PMC: 2891630. DOI: 10.1111/j.1582-4934.2009.00751.x. View

Loh N, Neville M, Marinou K, Hardcastle S, Fielding B, Duncan E . LRP5 regulates human body fat distribution by modulating adipose progenitor biology in a dose- and depot-specific fashion. Cell Metab. 2015; 21(2):262-273. PMC: 4321886. DOI: 10.1016/j.cmet.2015.01.009. View

Sienkiewicz E, Magkos F, Aronis K, Brinkoetter M, Chamberland J, Chou S . Long-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic women. Metabolism. 2011; 60(9):1211-21. DOI: 10.1016/j.metabol.2011.05.016. View

Limonard E, Veldhuis-Vlug A, van Dussen L, Runge J, Tanck M, Endert E . Short-Term Effect of Estrogen on Human Bone Marrow Fat. J Bone Miner Res. 2015; 30(11):2058-66. DOI: 10.1002/jbmr.2557. View

Duque G, Li W, Vidal C, Bermeo S, Rivas D, Henderson J . Pharmacological inhibition of PPARγ increases osteoblastogenesis and bone mass in male C57BL/6 mice. J Bone Miner Res. 2012; 28(3):639-48. DOI: 10.1002/jbmr.1782. View

Cinti S . The adipose organ. Prostaglandins Leukot Essent Fatty Acids. 2005; 73(1):9-15. DOI: 10.1016/j.plefa.2005.04.010. View

10.

Naveiras O, Nardi V, Wenzel P, Hauschka P, Fahey F, Daley G . Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature. 2009; 460(7252):259-63. PMC: 2831539. DOI: 10.1038/nature08099. View

11.

Patsch J, Li X, Baum T, Yap S, Karampinos D, Schwartz A . Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures. J Bone Miner Res. 2013; 28(8):1721-8. PMC: 3720702. DOI: 10.1002/jbmr.1950. View

12.

Botolin S, Faugere M, Malluche H, Orth M, Meyer R, McCabe L . Increased bone adiposity and peroxisomal proliferator-activated receptor-gamma2 expression in type I diabetic mice. Endocrinology. 2005; 146(8):3622-31. PMC: 1242186. DOI: 10.1210/en.2004-1677. View

13.

Long J, Svensson K, Tsai L, Zeng X, Roh H, Kong X . A smooth muscle-like origin for beige adipocytes. Cell Metab. 2014; 19(5):810-20. PMC: 4052772. DOI: 10.1016/j.cmet.2014.03.025. View

14.

Rendina-Ruedy E, Rosen C . Bone-Fat Interaction. Endocrinol Metab Clin North Am. 2017; 46(1):41-50. PMC: 5300693. DOI: 10.1016/j.ecl.2016.09.004. View

15.

Mizoguchi T, Pinho S, Ahmed J, Kunisaki Y, Hanoun M, Mendelson A . Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development. Dev Cell. 2014; 29(3):340-9. PMC: 4051418. DOI: 10.1016/j.devcel.2014.03.013. View

16.

Chou S, Chamberland J, Liu X, Matarese G, Gao C, Stefanakis R . Leptin is an effective treatment for hypothalamic amenorrhea. Proc Natl Acad Sci U S A. 2011; 108(16):6585-90. PMC: 3080974. DOI: 10.1073/pnas.1015674108. View

17.

Fan Y, Hanai J, Le P, Bi R, Maridas D, Demambro V . Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate. Cell Metab. 2017; 25(3):661-672. PMC: 5342925. DOI: 10.1016/j.cmet.2017.01.001. View

18.

Nuttall M, Shah F, Singh V, Thomas-Porch C, Frazier T, Gimble J . Adipocytes and the regulation of bone remodeling: a balancing act. Calcif Tissue Int. 2013; 94(1):78-87. DOI: 10.1007/s00223-013-9807-6. View

19.

Doucette C, Horowitz M, Berry R, MacDougald O, Anunciado-Koza R, Koza R . A High Fat Diet Increases Bone Marrow Adipose Tissue (MAT) But Does Not Alter Trabecular or Cortical Bone Mass in C57BL/6J Mice. J Cell Physiol. 2015; 230(9):2032-7. PMC: 4580244. DOI: 10.1002/jcp.24954. View

20.

Harms M, Ishibashi J, Wang W, Lim H, Goyama S, Sato T . Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab. 2014; 19(4):593-604. PMC: 4012340. DOI: 10.1016/j.cmet.2014.03.007. View