Insulin Signaling in Bone Marrow Adipocytes

Overview

Journal Curr Osteoporos Rep

Publisher Current Science

Specialties Endocrinology
Orthopedics

Date 2019 Nov 22

PMID 31749085

Citations 19

Authors

Michaela Tencerova

Meshail Okla

Moustapha Kassem

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: The goal of this review is to discuss the role of insulin signaling in bone marrow adipocyte formation, metabolic function, and its contribution to cellular senescence in relation to metabolic bone diseases.

Recent Findings: Insulin signaling is an evolutionally conserved signaling pathway that plays a critical role in the regulation of metabolism and longevity. Bone is an insulin-responsive organ that plays a role in whole body energy metabolism. Metabolic disturbances associated with obesity and type 2 diabetes increase a risk of fragility fractures along with increased bone marrow adiposity. In obesity, there is impaired insulin signaling in peripheral tissues leading to insulin resistance. However, insulin signaling is maintained in bone marrow microenvironment leading to hypermetabolic state of bone marrow stromal (skeletal) stem cells associated with accelerated senescence and accumulation of bone marrow adipocytes in obesity. This review summarizes current findings on insulin signaling in bone marrow adipocytes and bone marrow stromal (skeletal) stem cells and its importance for bone and fat metabolism. Moreover, it points out to the existence of differences between bone marrow and peripheral fat metabolism which may be relevant for developing therapeutic strategies for treatment of metabolic bone diseases.

Citing Articles

Bone Marrow Adipocytes as Novel Regulators of Metabolic Homeostasis: Clinical Consequences of Bone Marrow Adiposity.

Liu H, Liu L, Rosen C Curr Obes Rep. 2025; 14(1):9.

PMID: 39808256 DOI: 10.1007/s13679-024-00594-9.

A systematic review of the association between insulin resistance surrogate indices and bone mineral density.

Shirinezhad A, Azarboo A, Ghaseminejad-Raeini A, Kanaani Nejad F, Zareshahi N, Amiri S Front Endocrinol (Lausanne). 2025; 15:1499479.

PMID: 39744182 PMC: 11688183. DOI: 10.3389/fendo.2024.1499479.

Translational potential of mesenchymal stem cells in regenerative therapies for human diseases: challenges and opportunities.

Zhidu S, Ying T, Rui J, Chao Z Stem Cell Res Ther. 2024; 15(1):266.

PMID: 39183341 PMC: 11346273. DOI: 10.1186/s13287-024-03885-z.

Effects of Exercise on Bone Marrow Adipose Tissue in Children With Overweight/Obesity: Role of Liver Fat.

Labayen I, Cadenas-Sanchez C, Idoate F, Gracia-Marco L, Medrano M, Alfaro-Magallanes V J Clin Endocrinol Metab. 2024; 110(3):847-854.

PMID: 39109799 PMC: 11834710. DOI: 10.1210/clinem/dgae547.

Bone microarchitecture and strength assessed by HRpQCT in individuals with type 2 diabetes and prediabetes: the Maastricht study.

van Hulten V, Sarodnik C, Driessen J, Viggers R, Rasmussen N, Geusens P JBMR Plus. 2024; 8(9):ziae086.

PMID: 39108361 PMC: 11299510. DOI: 10.1093/jbmrpl/ziae086.

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