ER Proteostasis Control of Neuronal Physiology and Synaptic Function

Overview

Journal Trends Neurosci

Specialty Neurology

Date 2018 Jun 28

PMID 29945734

Citations 64

Authors

Gabriela Martinez

Sanjeev Khatiwada

Mauro Costa-Mattioli

Claudio Hetz

Affiliations

Soon will be listed here.

Abstract

Neuronal proteostasis is maintained by the dynamic integration of different processes that regulate the synthesis, folding, quality control, and localization of proteins. The endoplasmic reticulum (ER) serves as a fundamental pillar of the proteostasis network, and is emerging as a key compartment to sustain normal brain function. The unfolded protein response (UPR), the main mechanism that copes with ER stress, plays a central role in the quality control of many ion channels and receptors, in addition to crosstalk with signaling pathways that regulate connectivity, synapse formation, and neuronal plasticity. We provide here an overview of recent advances in the involvement of the UPR in maintaining neuronal proteostasis, and discuss its emerging role in brain development, neuronal physiology, and behavior, as well as the implications for neurodegenerative diseases involving cognitive decline.

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