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Acquisition of Beta-Lactamase by Neisseria Meningitidis Through Possible Horizontal Gene Transfer

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 2018 Jun 27
PMID 29941641
Citations 10
Authors
Eva Hong
Ala-Eddine Deghmane
Muhamed-Kheir Taha
Affiliations
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Abstract

We report the detection in France of a beta-lactamase-producing invasive meningococcal isolate. Whole-genome sequencing of the isolate revealed a ROB-1-type beta-lactamase gene that is frequently encountered in , suggesting horizontal transfer between isolates of these bacterial species. Beta-lactamases are exceptional in meningococci, with no reports for more than 2 decades. This report is worrying, as the expansion of such isolates may jeopardize the effective treatment against invasive meningococcal disease.

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