Beta-lactam Resistance in Haemophilus Parasuis Is Mediated by Plasmid PB1000 Bearing BlaROB-1

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2007 Apr 18

PMID 17438055

Citations 33

Authors

Alvaro San Millan

Jose Antonio Escudero

Ana Catalan

Silvia Nieto

Fidel Farelo

Magdalena Gibert

Miguel Angel Moreno

Lucas Dominguez

Bruno Gonzalez-Zorn

Affiliations

Soon will be listed here.

Abstract

beta-Lactam resistance in Haemophilus parasuis is an emerging phenomenon that has not yet been characterized from a molecular perspective. Clinical high-level beta-lactam-resistant isolates from Spain bore a novel plasmid, pB1000, expressing a functionally active ROB-1 beta-lactamase. Pulsed-field gel electrophoresis was applied for the first time to H. parasuis and showed that beta-lactam resistance is due to clonal spread of a resistant strain, BB1018, bearing pB1000.

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