Sensitivity of Peripheral Membrane Proteins to the Membrane Context: A Case Study of Phosphatidylserine and the TIM Proteins

Overview

Journal Biochim Biophys Acta Biomembr

Publisher Elsevier

Specialties Biochemistry
Biophysics
Cell Biology

Date 2018 Jun 20

PMID 29920237

Citations 11

Authors

Daniel Kerr

Gregory T Tietjen

Zhiliang Gong

Emad Tajkhorshid

Erin J Adams

Ka Yee C Lee

Affiliations

Soon will be listed here.

Abstract

There is a diverse class of peripheral membrane-binding proteins that specifically bind phosphatidylserine (PS), a lipid that signals apoptosis or cell fusion depending on the membrane context of its presentation. PS-receptors are specialized for particular PS-presenting pathways, indicating that they might be sensitive to the membrane context. In this review, we describe a combination of thermodynamic, structural, and computational techniques that can be used to investigate the mechanisms underlying this sensitivity. As an example, we focus on three PS-receptors of the T-cell Immunoglobulin and Mucin containing (TIM) protein family, which we have previously shown to differ in their sensitivity to PS surface density.

Citing Articles

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Tao J, Shen X, Qian H, Ding Q, Wang L Front Immunol. 2024; 15:1500228.

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Can calmodulin bind to lipids of the cytosolic leaflet of plasma membranes?.

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Husby M, Amiar S, Prugar L, David E, Plescia C, Huie K EMBO Rep. 2022; 23(11):e51709.

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