Does Bariatric Surgery Influence Plasma Levels of Fetuin-A and Leukocyte Cell-derived Chemotaxin-2 in Patients with Type 2 Diabetes Mellitus?

Overview

Journal PeerJ

Specialties Biology
Environmental Health
General Medicine

Date 2018 Jun 19

PMID 29910974

Citations 8

Authors

Hsien-Hao Huang

Chun Yeh

Jung-Chien Chen

Tzong-Hsi Lee

Shu-Chun Chen

Wei-Jei Lee

Chih-Yen Chen

Affiliations

Soon will be listed here.

Abstract

Background: Fetuin-A and leukocyte cell-derived chemotaxin-2 (LECT-2) are liver-derived proteins. Fetuin-A is an independent risk factor for type 2 diabetes (T2D) and obese patients with T2D have higher plasma fetuin-A levels than those without T2D. LECT-2 has positive correlation with the severity of both obesity and insulin resistance. The changes in plasma fetuin-A are not consistent after bariatric surgery and no studies have investigated the changes in LECT-2 on the obese patients with T2D after bariatric surgery.

Methods: Overall, 18 patients undergoing gastric bypass (GB) and 16 patients undergoing sleeve gastrectomy (SG) were enrolled. The fasting plasma fetuin-A and LECT-2 levels were measured at baseline, one week, three months, and one year after surgery.

Results: Both the GB and SG groups significantly decreased the body mass index (BMI), waist-to-hip ratio, a body shape index; the triglyceride, fasting blood sugar (FBS), hemoglobin A1c, C-peptide levels; and homeostatic model assessment (HOMA-IR) one year after surgery. The SG group showed a decreasing trend in plasma fetuin-A levels one year after SG surgery. There are no significant changes in LECT-2 one year after either GB or SG. Fetuin-A had a near significant negative relationship with insulin ( = 0.056) and HOMA-IR ( = 0.050) in the SG group. Changes in fetuin-A had a significant positive relationship with changes in BMI ( = 0.031) and waist-to-hip ratio ( = 0.031) in the GB group and had a near significant positive correlation with FBS ( = 0.051) in the SG group.

Discussion: Neither GB nor SG modifies plasma levels of plasma fetuin-A or LECT-2 in T2D patients after surgery. The changes in plasma fetuin-A have a positive correlation with those of the BMI and waist-to-hip ratio 12 months after GB.

Citing Articles

Organokines, Sarcopenia, and Metabolic Repercussions: The Vicious Cycle and the Interplay with Exercise.

Minniti G, Pescinini-Salzedas L, Minniti G, Fornari Laurindo L, Barbalho S, Sinatora R Int J Mol Sci. 2022; 23(21).

PMID: 36362238 PMC: 9655425. DOI: 10.3390/ijms232113452.

Impact of Metabolic Surgery on Gut Microbiota and Sera Metabolomic Patterns among Patients with Diabetes.

Huang H, Lin T, Lee W, Chen S, Lai W, Lu C Int J Mol Sci. 2022; 23(14).

PMID: 35887145 PMC: 9320451. DOI: 10.3390/ijms23147797.

DIA-Based Proteomic Analysis of Plasma Protein Profiles in Patients with Severe Acute Pancreatitis.

Li H, Xu Y, Zhou X, Jin T, Wang Z, Sun Y Molecules. 2022; 27(12).

PMID: 35745003 PMC: 9230633. DOI: 10.3390/molecules27123880.

Effects of Bariatric Surgeries on Fetuin-A, Selenoprotein P, Angiopoietin-Like Protein 6, and Fibroblast Growth Factor 21 Concentration.

Poloczek J, Kazura W, Kwasnicka E, Gumprecht J, Jochem J, Stygar D J Diabetes Res. 2021; 2021:5527107.

PMID: 34414240 PMC: 8369187. DOI: 10.1155/2021/5527107.

Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl:ZUC(ORL)-Lepr) rats.

Stygar D, Sawczyn T, Dulska A, Chelmecka E, Mielanczyk L, Matysiak N Sci Rep. 2021; 11(1):7774.

PMID: 33833309 PMC: 8032747. DOI: 10.1038/s41598-021-87293-w.

References

Brix J, Stingl H, Hollerl F, Schernthaner G, Kopp H, Schernthaner G . Elevated Fetuin-A concentrations in morbid obesity decrease after dramatic weight loss. J Clin Endocrinol Metab. 2010; 95(11):4877-81. DOI: 10.1210/jc.2010-0148. View

Kahraman A, Sowa J, Schlattjan M, Sydor S, Pronadl M, Wree A . Fetuin-A mRNA expression is elevated in NASH compared with NAFL patients. Clin Sci (Lond). 2013; 125(8):391-400. DOI: 10.1042/CS20120542. View

Lee W, Almulaifi A, Tsou J, Ser K, Lee Y, Chen S . Laparoscopic sleeve gastrectomy for type 2 diabetes mellitus: predicting the success by ABCD score. Surg Obes Relat Dis. 2015; 11(5):991-6. DOI: 10.1016/j.soard.2014.12.027. View

Chiu C, Lee W, Wang W, Wei P, Huang M . Prevention of trocar-wound hernia in laparoscopic bariatric operations. Obes Surg. 2006; 16(7):913-8. DOI: 10.1381/096089206777822269. View

Schauer P, Bhatt D, Kirwan J, Wolski K, Brethauer S, Navaneethan S . Bariatric surgery versus intensive medical therapy for diabetes--3-year outcomes. N Engl J Med. 2014; 370(21):2002-13. PMC: 5451259. DOI: 10.1056/NEJMoa1401329. View

Stefan N, Fritsche A, Weikert C, Boeing H, Joost H, Haring H . Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes. 2008; 57(10):2762-7. PMC: 2551687. DOI: 10.2337/db08-0538. View

Blackburn G, Mun E . Effects of weight loss surgeries on liver disease. Semin Liver Dis. 2004; 24(4):371-9. DOI: 10.1055/s-2004-860866. View

Chen Y, Inui A, Chang E, Chen S, Lee W, Chen C . Comparison of gut hormones and adipokines stimulated by glucagon test among patients with type II diabetes mellitus after metabolic surgery. Neuropeptides. 2015; 55:39-45. DOI: 10.1016/j.npep.2015.11.002. View

Klein S, Mittendorfer B, Eagon J, Patterson B, Grant L, Feirt N . Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology. 2006; 130(6):1564-72. DOI: 10.1053/j.gastro.2006.01.042. View

10.

Reinehr T, Roth C . Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss. J Clin Endocrinol Metab. 2008; 93(11):4479-85. DOI: 10.1210/jc.2008-1505. View

11.

Ogurtsova K, da Rocha Fernandes J, Huang Y, Linnenkamp U, Guariguata L, Cho N . IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract. 2017; 128:40-50. DOI: 10.1016/j.diabres.2017.03.024. View

12.

Jullig M, Yip S, Xu A, Smith G, Middleditch M, Booth M . Lower fetuin-A, retinol binding protein 4 and several metabolites after gastric bypass compared to sleeve gastrectomy in patients with type 2 diabetes. PLoS One. 2014; 9(5):e96489. PMC: 4011803. DOI: 10.1371/journal.pone.0096489. View

13.

Chen C, Lee W, Asakawa A, Fujitsuka N, Chong K, Chen S . Insulin secretion and interleukin-1β dependent mechanisms in human diabetes remission after metabolic surgery. Curr Med Chem. 2013; 20(18):2374-88. DOI: 10.2174/0929867311320180008. View

14.

Ali S, Nassif W, Abdelaziz D . Alterations in serum levels of fetuin A and selenoprotein P in chronic hepatitis C patients with concomitant type 2 diabetes: A case-control study. Clin Res Hepatol Gastroenterol. 2016; 40(4):465-70. DOI: 10.1016/j.clinre.2015.12.003. View

15.

Erdmann J, Salmhofer H, Knauss A, Mayr M, Wagenpfeil S, Sypchenko O . Relationship of fetuin-A levels to weight-dependent insulin resistance and type 2 diabetes mellitus. Regul Pept. 2012; 178(1-3):6-10. DOI: 10.1016/j.regpep.2012.02.004. View

16.

Mathews S, Chellam N, Srinivas P, Cintron V, Leon M, Goustin A . Alpha2-HSG, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor. Mol Cell Endocrinol. 2000; 164(1-2):87-98. DOI: 10.1016/s0303-7207(00)00237-9. View

17.

Lee W, Hur K, Lakadawala M, Kasama K, Wong S, Chen S . Predicting success of metabolic surgery: age, body mass index, C-peptide, and duration score. Surg Obes Relat Dis. 2012; 9(3):379-84. DOI: 10.1016/j.soard.2012.07.015. View

18.

Mattar S, Velcu L, Rabinovitz M, Demetris A, Krasinskas A, Barinas-Mitchell E . Surgically-induced weight loss significantly improves nonalcoholic fatty liver disease and the metabolic syndrome. Ann Surg. 2005; 242(4):610-7. PMC: 1402345. DOI: 10.1097/01.sla.0000179652.07502.3f. View

19.

Yang P, Ser K, Lin M, Nien H, Chen C, Yang W . Diabetes Associated Markers After Bariatric Surgery: Fetuin-A, but Not Matrix Metalloproteinase-7, Is Reduced. Obes Surg. 2015; 25(12):2328-34. DOI: 10.1007/s11695-015-1688-5. View

20.

Higa K, Ho T, Tercero F, Yunus T, Boone K . Laparoscopic Roux-en-Y gastric bypass: 10-year follow-up. Surg Obes Relat Dis. 2011; 7(4):516-25. DOI: 10.1016/j.soard.2010.10.019. View