Effects of Bariatric Surgeries on Fetuin-A, Selenoprotein P, Angiopoietin-Like Protein 6, and Fibroblast Growth Factor 21 Concentration

Overview

Journal J Diabetes Res

Publisher Wiley

Specialty Endocrinology

Date 2021 Aug 20

PMID 34414240

Citations 4

Authors

Jakub Poloczek

Wojciech Kazura

Ewa Kwasnicka

Janusz Gumprecht

Jerzy Jochem

Dominika Stygar

Affiliations

Soon will be listed here.

Abstract

Obesity is a civilization disease representing a global health problem. Excessive body weight significantly reduces the quality of life. It is also associated with the leading causes of death, including type 2 , cardiovascular diseases, and numerous types of cancer. The mainstay of therapy is a dietary treatment. However, in morbidly obese patients, dietary treatment is often insufficient. In these patients, the most effective procedure is bariatric surgery, but it is still difficult to predict its outcome and metabolic changes. Hepatokines are proteins secreted by hepatocytes. Many of them, including fetuin-A, selenoprotein P, angiopoietin-like protein 6, and fibroblast growth factor 21, have been linked to metabolic dysfunctions. In this context, hepatokines may prove helpful. This review investigates the possible changes in hepatokine profiles after selected bariatric surgery protocols. In this regard, gastric bypass is the most studied type of surgery. The overall analysis of published research identified fetuin-A as a potential marker of metabolic alternations in patients after bariatric surgery.

Citing Articles

3-Month Post-Operative Increase in FGF21 is Predictive of One-Year Weight Loss After Bariatric Surgery.

De Luca A, Delaye J, Fauchier G, Bourbao-Tournois C, Champion H, Bourdon G Obes Surg. 2023; 33(8):2468-2474.

PMID: 37391682 DOI: 10.1007/s11695-023-06702-3.

Duodenojejunal Omega Switch Surgery Reduces Oxidative Stress Induced by Cafeteria Diet in Sprague-Dawley Rats.

Poloczek J, Kazura W, Chelmecka E, Michalczyk K, Jochem J, Gumprecht J Nutrients. 2022; 14(19).

PMID: 36235749 PMC: 9573765. DOI: 10.3390/nu14194097.

Serum Fibrinogen-Like Protein 1 Levels in Obese Patients Before and After Laparoscopic Sleeve Gastrectomy: A Six-Month Longitudinal Study.

Dilimulati D, Du L, Huang X, Jayachandran M, Cai M, Zhang Y Diabetes Metab Syndr Obes. 2022; 15:2511-2520.

PMID: 35999870 PMC: 9393035. DOI: 10.2147/DMSO.S374011.

Role of ANGPTL8 in NAFLD Improvement after Bariatric Surgery in Experimental and Human Obesity.

Perdomo C, Gomez-Ambrosi J, Becerril S, Valenti V, Moncada R, Fernandez-Saez E Int J Mol Sci. 2021; 22(23).

PMID: 34884755 PMC: 8657645. DOI: 10.3390/ijms222312945.

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