IL-10/STAT3 is Reduced in Childhood Obesity with Hypertriglyceridemia and is Related to Triglyceride Level in Diet-induced Obese Rats

Overview

Journal BMC Endocr Disord

Publisher Biomed Central

Specialty Endocrinology

Date 2018 Jun 14

PMID 29895283

Citations 24

Authors

Yuesheng Liu

Dong Xu

Chunyan Yin

Sisi Wang

Min Wang

Yanfeng Xiao

Affiliations

Soon will be listed here.

Abstract

Background: The prevalence of childhood obesity and obesity-related metabolic disorder such as dyslipidemia has sharply increased in the past few decades. Chronic low-grade inflammation is associated with the development of comorbidities and poor prognosis in obesity. This study aims to evaluate interleukin-10 (IL-10) in childhood obesity with hypertriglyceridemia.

Method: We evaluated IL-10 and signal transducer and activator of transcription 3 (STAT3) mRNA expression in adipose tissue (AT) as well as serum IL-10 in 62 children of 3 groups and in high-fat diet (HFD) induced obese rat. Expression of IL-10 and STAT3 protein in AT of diet-induced obese rats were examined over feed period.

Results: Adipose IL-10 and STAT3 mRNA expression and serum IL-10 reduced in obese children with hypertriglyceridemia and in HFD obese rats. The protein expression of IL-10 and STAT3 decreased in AT of obese rats compared with the control rats at end time. Expression of IL-10 mRNA was negatively correlated to TG and LDL-C levels, and positively correlated to HDL-C, adiponectin and serum IL-10 levels.

Conclusions: IL-10 expression and its downstream JAK-STAT pathway are down-regulated in obese children with hypertriglyceridemia and in HFD obese rats.

Citing Articles

Rosehip Extract Decreases Reactive Oxygen Species Production and Lipid Accumulation in Hypertrophic 3T3-L1 Adipocytes with the Modulation of Inflammatory State.

Kowalska K, Olejnik A Nutrients. 2024; 16(19).

PMID: 39408236 PMC: 11478984. DOI: 10.3390/nu16193269.

IL-10 and IL-1β Serum Levels, Genetic Variants, and Metabolic Syndrome: Insights into Older Adults' Clinical Characteristics.

Freitas R, de Souza Silva C, Fratelli C, Lima L, Stival M, Funghetto S Nutrients. 2024; 16(8).

PMID: 38674931 PMC: 11053558. DOI: 10.3390/nu16081241.

Association of baseline and changes in adiponectin, homocysteine, high-sensitivity C-reactive protein, interleukin-6, and interleukin-10 levels and metabolic syndrome incidence: Tehran lipid and glucose study.

Zahedi A, Daneshpour M, Akbarzadeh M, Hedayati M, Azizi F, Zarkesh M Heliyon. 2023; 9(9):e19911.

PMID: 37809533 PMC: 10559325. DOI: 10.1016/j.heliyon.2023.e19911.

Impact of Western Diet and Ultra-Processed Food on the Intestinal Mucus Barrier.

Stolfi C, Pacifico T, Monteleone G, Laudisi F Biomedicines. 2023; 11(7).

PMID: 37509654 PMC: 10377275. DOI: 10.3390/biomedicines11072015.

Chronic treatment with IL-25 increases renal M2 macrophages and reduces renal injury in obese Dahl salt-sensitive rats during the prepubescent stage.

Poudel B, Ekperikpe U, Mandal S, Wilson G, Shields C, Cornelius D Am J Physiol Renal Physiol. 2023; 325(1):F87-F98.

PMID: 37167270 PMC: 10292980. DOI: 10.1152/ajprenal.00209.2022.

References

Dunford L, Langley-Evans S, McMullen S . Childhood obesity and risk of the adult metabolic syndrome: a systematic review. Int J Obes (Lond). 2011; 36(1):1-11. PMC: 3255098. DOI: 10.1038/ijo.2011.186. View

Lee A, Gurka M, DeBoer M . Trends in Metabolic Syndrome Severity and Lifestyle Factors Among Adolescents. Pediatrics. 2016; 137(3):e20153177. PMC: 4771130. DOI: 10.1542/peds.2015-3177. View

Schaalan M, Ramadan B, Elwahab A . Synergistic effect of carnosine on browning of adipose tissue in exercised obese rats; a focus on circulating irisin levels. J Cell Physiol. 2017; 233(6):5044-5057. DOI: 10.1002/jcp.26370. View

van Greevenbroek M, Schalkwijk C, Stehouwer C . Obesity-associated low-grade inflammation in type 2 diabetes mellitus: causes and consequences. Neth J Med. 2013; 71(4):174-87. View

Sabat R, Grutz G, Warszawska K, Kirsch S, Witte E, Wolk K . Biology of interleukin-10. Cytokine Growth Factor Rev. 2010; 21(5):331-44. DOI: 10.1016/j.cytogfr.2010.09.002. View

Hawcutt D, Bellis J, Price V, Povall A, Newland P, Richardson P . Growth hormone prescribing and initial BMI SDS: Increased biochemical adverse effects and costs in obese children without additional gain in height. PLoS One. 2017; 12(7):e0181567. PMC: 5513545. DOI: 10.1371/journal.pone.0181567. View

Medeiros N, Mattos R, Menezes C, Fares R, Talvani A, Dutra W . IL-10 and TGF-β unbalanced levels in neutrophils contribute to increase inflammatory cytokine expression in childhood obesity. Eur J Nutr. 2017; 57(7):2421-2430. DOI: 10.1007/s00394-017-1515-y. View

Pereira S, Teixeira L, Aguilar E, Oliveira M, Savassi-Rocha A, Pelaez J . Modulation of adipose tissue inflammation by FOXP3+ Treg cells, IL-10, and TGF-β in metabolically healthy class III obese individuals. Nutrition. 2014; 30(7-8):784-90. DOI: 10.1016/j.nut.2013.11.023. View

Sun K, Kusminski C, Scherer P . Adipose tissue remodeling and obesity. J Clin Invest. 2011; 121(6):2094-101. PMC: 3104761. DOI: 10.1172/JCI45887. View

10.

Li S, Zhang H, Hu C, Lawrence F, Gallagher K, Surapaneni A . Assessment of diet-induced obese rats as an obesity model by comparative functional genomics. Obesity (Silver Spring). 2008; 16(4):811-8. DOI: 10.1038/oby.2007.116. View

11.

Doerrler W, Feingold K, Grunfeld C . Cytokines induce catabolic effects in cultured adipocytes by multiple mechanisms. Cytokine. 1994; 6(5):478-84. DOI: 10.1016/1043-4666(94)90074-4. View

12.

Watt M, Carey A, Wolsk-Petersen E, Kraemer F, Pedersen B, Febbraio M . Hormone-sensitive lipase is reduced in the adipose tissue of patients with type 2 diabetes mellitus: influence of IL-6 infusion. Diabetologia. 2004; 48(1):105-12. DOI: 10.1007/s00125-004-1598-x. View

13.

Stark G, Darnell Jr J . The JAK-STAT pathway at twenty. Immunity. 2012; 36(4):503-14. PMC: 3909993. DOI: 10.1016/j.immuni.2012.03.013. View

14.

Wolska A, Dunbar R, Freeman L, Ueda M, Amar M, Sviridov D . Apolipoprotein C-II: New findings related to genetics, biochemistry, and role in triglyceride metabolism. Atherosclerosis. 2017; 267:49-60. PMC: 5705268. DOI: 10.1016/j.atherosclerosis.2017.10.025. View

15.

Skurk T, Alberti-Huber C, Herder C, Hauner H . Relationship between adipocyte size and adipokine expression and secretion. J Clin Endocrinol Metab. 2006; 92(3):1023-33. DOI: 10.1210/jc.2006-1055. View

16.

Tanianskii D, Firova E, Shatilina L, Denisenko A . [Adiponectin: lowering in metabolic syndrome and independent relation to hypertriglyceridemia]. Kardiologiia. 2008; 48(12):20-5. View

17.

Mattos R, Medeiros N, Menezes C, Fares R, Franco E, Dutra W . Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets. PLoS One. 2016; 11(12):e0168610. PMC: 5158089. DOI: 10.1371/journal.pone.0168610. View

18.

Kopelman P . Health risks associated with overweight and obesity. Obes Rev. 2007; 8 Suppl 1:13-7. DOI: 10.1111/j.1467-789X.2007.00311.x. View

19.

Sun H, Ma Y, Han D, Pan C, Xu Y . Prevalence and trends in obesity among China's children and adolescents, 1985-2010. PLoS One. 2014; 9(8):e105469. PMC: 4139359. DOI: 10.1371/journal.pone.0105469. View

20.

Cox A, West N, Cripps A . Obesity, inflammation, and the gut microbiota. Lancet Diabetes Endocrinol. 2014; 3(3):207-15. DOI: 10.1016/S2213-8587(14)70134-2. View