The Effect of Gene Polymorphism on Obesity Parameters in Highly Physically Active Young Men

Overview

Journal Biol Sport

Specialty Orthopedics

Date 2022 Oct 17

PMID 36247965

Authors

Ewelina Maculewicz

Andrzej Mastalerz

Bozena Antkowiak

Oktawiusz Antkowiak

Aleksandra Garbacz

Ewa Szarska

Pawel Rusin

Anna Cywinska

Agnieszka Bialek

Pawel Cieszczyk

Affiliations

Soon will be listed here.

Abstract

The main aim of this study was to investigate the association between 5 polymorphisms of the interleukin 10 () gene and body composition parameters in physically active young men. A cohort of 131 young men was enrolled and the following single-nucleotide polymorphisms (SNPs) were analysed: rs1518111, rs1878672, rs3024496, rs3024498 and rs3024505. The subjects were divided into groups depending on obesity parameters: body mass index (BMI) and percentage of body fat tissue (fat %). Statistical analysis was conducted for alleles, genotypes and haplotypes, and an association between SNPs and body composition parameters was analysed using four genetic models: dominant, recessive, codominant and overdominant mode of inheritance (MOI). The only statistically significant result in polymorphisms was found for rs3024505 in the over-dominant model with BMI (p = 0.04) and with fat % (p = 0.02). The haplo.score function showed an association between BMI and CCGTA (respectively) haplotype in the additive model (score = -2.00, p = 0.04) and in the dominant model (score = -2.30, p = 0.02). The obtained results indicate a statistically significant contribution of selected polymorphisms in the regulation of body weight in physically active individuals.

Citing Articles

Systematic Review of , , , , , and Gene Polymorphisms and Meta-Analysis of Variant and Its Association with Overweight and Obesity Risk in Men.

Bojarczuk A, Garbacz A, Zekanowski C, Borzemska B, Cieszczyk P, Maculewicz E Int J Mol Sci. 2025; 25(24.

PMID: 39769263 PMC: 11679641. DOI: 10.3390/ijms252413501.

Association of the and polymorphisms with posttraining changes in body mass, composition, and biochemical parameters in Caucasian women.

Leonska-Duniec A, Lepionka W, Brodkiewicz A, Buryta M Biol Sport. 2024; 41(2):47-56.

PMID: 38524816 PMC: 10955753. DOI: 10.5114/biolsport.2024.131415.

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