Incorporating Mechanical Strain in Organs-on-a-chip: Lung and Skin

Overview

Journal Biomicrofluidics

Publisher American Institute of Physics

Specialty Biomedical Engineering

Date 2018 Jun 5

PMID 29861818

Citations 34

Authors

Olivier T Guenat

Francois Berthiaume

Affiliations

Soon will be listed here.

Abstract

In the last decade, the advent of microfabrication and microfluidics and an increased interest in cellular mechanobiology have triggered the development of novel microfluidic-based platforms. They aim to incorporate the mechanical strain environment that acts upon tissues and barriers of the human body. This article reviews those platforms, highlighting the different strains applied, and the actuation mechanisms and provides representative applications. A focus is placed on the skin and the lung barriers as examples, with a section that discusses the signaling pathways involved in the epithelium and the connective tissues.

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