Load and Failure Behavior of Human Muscle Samples in the Context of Proximal Femur Replacement

Overview

Journal BMC Musculoskelet Disord

Publisher Biomed Central

Specialties Orthopedics
Physiology

Date 2016 Apr 7

PMID 27048598

Citations 6

Authors

Stefan Schleifenbaum

Michael Schmidt

Robert Mobius

Thomas Wolfskampf

Christian Schroder

Ronny Grunert

Niels Hammer

Torsten Prietzel

Affiliations

Soon will be listed here.

Abstract

Background: To ensure adequate function after orthopedic tumor reconstruction, it is important to reattach the remaining soft tissue to the implant. This study aimed at obtaining mechanical properties of textile muscle-implant and muscle-bone connections in a preliminary test.

Methods: Two groups of soft-tissue attachment were mechanically tested and compared: Native bone-muscle samples obtained from human femora and muscles attached to a prosthetic implant by means of Trevira® attachment tubes. Additionally, muscle samples were tested with muscle fibers aligned parallel and perpendicular to the tension load. A uniaxial load was exerted upon all samples.

Results: Failure loads of 26.7 ± 8.8 N were observed for the native bone-muscle group and of 18.1 ± 9.9 N for the Trevira® group. Elongations of 94.8 ± 36.2 % were observed for the native bone-muscle group and 79.3 ± 51.8 % for the Trevira® group. The location of failure was mainly observed in the central area of the muscle fibers. Muscle fibers with parallel fiber orientation (47.6 ± 11.5 N) yielded higher tensile strength than those with perpendicular fiber orientation (14.8 ± 4.1 N).

Conclusions: Our experiments showed that higher forces were transmitted in the origin and insertion areas than in areas of flat soft tissue reconstruction using attachment tubes. The data indicate that the tested material allows reattaching muscles, but without reinforcing the insertion site. Therefore, attachment tubes with region-dependent and potentially anisotropic material behavior might be advantageous to optimize muscle-bone load transmission after surgery, which may allow lower complication rates and shorter physical recovery.

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References

Komatsu F, Mori R, Uchio Y . Optimum surgical suture material and methods to obtain high tensile strength at knots: problems of conventional knots and the reinforcement effect of adhesive agent. J Orthop Sci. 2006; 11(1):70-4. DOI: 10.1007/s00776-005-0973-x. View

Kot B, Zhang Z, Lee A, Leung V, Fu S . Elastic modulus of muscle and tendon with shear wave ultrasound elastography: variations with different technical settings. PLoS One. 2012; 7(8):e44348. PMC: 3432131. DOI: 10.1371/journal.pone.0044348. View

Pietschmann M, Frohlich V, Ficklscherer A, Hausdorf J, Utzschneider S, Jansson V . Pullout strength of suture anchors in comparison with transosseous sutures for rotator cuff repair. Knee Surg Sports Traumatol Arthrosc. 2008; 16(5):504-10. DOI: 10.1007/s00167-007-0460-3. View

Lexell J . Human aging, muscle mass, and fiber type composition. J Gerontol A Biol Sci Med Sci. 1995; 50 Spec No:11-6. DOI: 10.1093/gerona/50a.special_issue.11. View

Jeys L, Grimer R . The long-term risks of infection and amputation with limb salvage surgery using endoprostheses. Recent Results Cancer Res. 2009; 179:75-84. DOI: 10.1007/978-3-540-77960-5_7. View

Wirganowicz P, Eckardt J, Dorey F, Eilber F, Kabo J . Etiology and results of tumor endoprosthesis revision surgery in 64 patients. Clin Orthop Relat Res. 1999; (358):64-74. View

Gosheger G, Hillmann A, Lindner N, Rodl R, Hoffmann C, Burger H . Soft tissue reconstruction of megaprostheses using a trevira tube. Clin Orthop Relat Res. 2002; (393):264-71. DOI: 10.1097/00003086-200112000-00030. View

Van Ee C, Chasse A, Myers B . Quantifying skeletal muscle properties in cadaveric test specimens: effects of mechanical loading, postmortem time, and freezer storage. J Biomech Eng. 2000; 122(1):9-14. DOI: 10.1115/1.429621. View

Jagodzinski M, Ettinger M, Haasper C, Hankemeier S, Breitmeier D, Hurschler C . [Biomechanical analysis of press-fit fixation of anterior cruciate ligament transplants]. Unfallchirurg. 2010; 113(7):532-9. DOI: 10.1007/s00113-010-1788-6. View

10.

Raiss P, Kinkel S, Sauter U, Bruckner T, Lehner B . Replacement of the proximal humerus with MUTARS tumor endoprostheses. Eur J Surg Oncol. 2009; 36(4):371-7. DOI: 10.1016/j.ejso.2009.11.001. View

11.

Roberts P, Chan D, Grimer R, Sneath R, Scales J . Prosthetic replacement of the distal femur for primary bone tumours. J Bone Joint Surg Br. 1991; 73(5):762-9. DOI: 10.1302/0301-620X.73B5.1894662. View

12.

Hardes J, Gebert C, Schwappach A, Ahrens H, Streitburger A, Winkelmann W . Characteristics and outcome of infections associated with tumor endoprostheses. Arch Orthop Trauma Surg. 2006; 126(5):289-96. DOI: 10.1007/s00402-005-0009-1. View

13.

Kuthe C, Uddanwadiker R, Ramteke A . Experimental evaluation of fiber orientation based material properties of skeletal muscle in tension. Mol Cell Biomech. 2015; 11(2):113-28. View

14.

Fukunaga T, Ichinose Y, Ito M, Kawakami Y, Fukashiro S . Determination of fascicle length and pennation in a contracting human muscle in vivo. J Appl Physiol (1985). 1997; 82(1):354-8. DOI: 10.1152/jappl.1997.82.1.354. View

15.

Pietschmann M, Sadoghi P, Hauser E, Scharpf A, Gulecyuz M, Schroder C . Influence of testing conditions on primary stability of arthroscopic knot tying for rotator cuff repair: slippery when wet?. Arthroscopy. 2011; 27(12):1628-36. DOI: 10.1016/j.arthro.2011.06.031. View

16.

Mavrogenis A, Ruggieri P, Mercuri M, Papagelopoulos P . Megaprosthetic reconstruction for malignant bone tumors: complications and outcomes. J Long Term Eff Med Implants. 2009; 18(3):239-51. DOI: 10.1615/jlongtermeffmedimplants.v18.i3.40. View

17.

Muramatsu T, Muraoka T, Kawakami Y, Shibayama A, Fukunaga T . In vivo determination of fascicle curvature in contracting human skeletal muscles. J Appl Physiol (1985). 2001; 92(1):129-34. DOI: 10.1152/jappl.2002.92.1.129. View

18.

Hardes J, Ahrens H, Nottrott M, Dieckmann R, Gosheger G, Henrichs M . [Attachment tube for soft tissue reconstruction after implantation of a mega-endoprosthesis]. Oper Orthop Traumatol. 2012; 24(3):227-34. DOI: 10.1007/s00064-011-0080-4. View

19.

Heisel C, Breusch S, Schmid G, Bernd L . Lower limb salvage surgery with MUTARS endoprostheses: 2 to 7 year results. Acta Orthop Belg. 2004; 70(2):142-7. View

20.

Takaza M, Moerman K, Gindre J, Lyons G, Simms C . The anisotropic mechanical behaviour of passive skeletal muscle tissue subjected to large tensile strain. J Mech Behav Biomed Mater. 2012; 17:209-20. DOI: 10.1016/j.jmbbm.2012.09.001. View