The Role of Cancer-associated Fibroblasts in Tumorigenesis of Gastric Cancer

Overview

Journal Curr Pharm Des

Publisher Bentham Science Publishers

Date 2018 Jun 2

PMID 29852862

Citations 17

Authors

Zhilong Ma

Min Chen

Xiaohu Yang

Bin Xu

Zhenshun Song

Bo Zhou

Tingsong Yang

Affiliations

Soon will be listed here.

Abstract

Cancer-associated fibroblasts (CAFs) are an important cell type present in solid tumor microenvironments, including that of gastric cancer. They play a vital role in the promotion of tumorigenesis, angiogenesis, and cancer progression through paracrine signaling and modulation of the extracellular matrix. However, the exact molecular mechanism underlying the interaction between gastric cancer cells and stromal fibroblasts remains poorly understood. Recent studies have demonstrated that various factors, such as gene and microRNA variations, are involved in this process. This review discusses recent advances in understanding how these factors are regulated in CAFs and how they affect tumor biology, which may improve our understanding of their role in gastric cancer tumorigenesis and progression and provide new promising targets for therapeutic strategies.

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