Exosomes Promote Pre-Metastatic Niche Formation in Gastric Cancer

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Jun 10

PMID 34109113

Citations 20

Authors

Jing Gao

Song Li

Qian Xu

Xue Zhang

Miao Huang

Xin Dai

Lian Liu

Affiliations

Soon will be listed here.

Abstract

Gastric cancer has a high rate of metastasis, during which pre-metastatic niches (PMN) provide a supportive environment for the upcoming tumor cells. Exosomes are bilayer vesicles secreted by cells containing biological information that mediates communication between cells. Using exosomes, gastric cancer cells establish PMN remotely in multifarious perspectives, including immunosuppression, stroma remodeling, angiogenesis, mesothelial mesenchymal transformation, and organotropism. In turn, the cell components in PMN secrete exosomes that interact with each other and provide onco-promoting signals. In this review, we highlight the role of exosomes in PMN formation in gastric cancer and discuss their potential values in gastric cancer metastasis diagnosis, prevention, and treatment.

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References

Wang J, Lv B, Su Y, Wang X, Bu J, Yao L . Exosome-Mediated Transfer of lncRNA HOTTIP Promotes Cisplatin Resistance in Gastric Cancer Cells by Regulating HMGA1/miR-218 Axis. Onco Targets Ther. 2020; 12:11325-11338. PMC: 6930390. DOI: 10.2147/OTT.S231846. View

Kanda M, Kodera Y . Molecular mechanisms of peritoneal dissemination in gastric cancer. World J Gastroenterol. 2016; 22(30):6829-40. PMC: 4974582. DOI: 10.3748/wjg.v22.i30.6829. View

Zhu W, Huang L, Li Y, Zhang X, Gu J, Yan Y . Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo. Cancer Lett. 2011; 315(1):28-37. DOI: 10.1016/j.canlet.2011.10.002. View

Wang J, Guan X, Zhang Y, Ge S, Zhang L, Li H . Exosomal miR-27a Derived from Gastric Cancer Cells Regulates the Transformation of Fibroblasts into Cancer-Associated Fibroblasts. Cell Physiol Biochem. 2018; 49(3):869-883. DOI: 10.1159/000493218. View

Sandoval P, Jimenez-Heffernan J, Rynne-Vidal A, Perez-Lozano M, Gilsanz A, Ruiz-Carpio V . Carcinoma-associated fibroblasts derive from mesothelial cells via mesothelial-to-mesenchymal transition in peritoneal metastasis. J Pathol. 2013; 231(4):517-31. DOI: 10.1002/path.4281. View

Zhang H, Wang Y, Bai M, Wang J, Zhu K, Liu R . Exosomes serve as nanoparticles to suppress tumor growth and angiogenesis in gastric cancer by delivering hepatocyte growth factor siRNA. Cancer Sci. 2017; 109(3):629-641. PMC: 5834801. DOI: 10.1111/cas.13488. View

Thomassen I, van Gestel Y, van Ramshorst B, Luyer M, Bosscha K, Nienhuijs S . Peritoneal carcinomatosis of gastric origin: a population-based study on incidence, survival and risk factors. Int J Cancer. 2013; 134(3):622-8. DOI: 10.1002/ijc.28373. View

Gu J, Qian H, Shen L, Zhang X, Zhu W, Huang L . Gastric cancer exosomes trigger differentiation of umbilical cord derived mesenchymal stem cells to carcinoma-associated fibroblasts through TGF-β/Smad pathway. PLoS One. 2013; 7(12):e52465. PMC: 3527492. DOI: 10.1371/journal.pone.0052465. View

Xu G, Zhang B, Ye J, Cao S, Shi J, Zhao Y . Exosomal miRNA-139 in cancer-associated fibroblasts inhibits gastric cancer progression by repressing MMP11 expression. Int J Biol Sci. 2019; 15(11):2320-2329. PMC: 6775321. DOI: 10.7150/ijbs.33750. View

10.

Umakoshi M, Takahashi S, Itoh G, Kuriyama S, Sasaki Y, Yanagihara K . Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment. Oncogene. 2018; 38(12):2162-2176. DOI: 10.1038/s41388-018-0564-x. View

11.

Grunwald B, Harant V, Schaten S, Fruhschutz M, Spallek R, Hochst B . Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver. Gastroenterology. 2016; 151(5):1011-1024.e7. DOI: 10.1053/j.gastro.2016.07.043. View

12.

Ingenito F, Roscigno G, Affinito A, Nuzzo S, Scognamiglio I, Quintavalle C . The Role of Exo-miRNAs in Cancer: A Focus on Therapeutic and Diagnostic Applications. Int J Mol Sci. 2019; 20(19). PMC: 6801421. DOI: 10.3390/ijms20194687. View

13.

Chin A, Wang S . Cancer Tills the Premetastatic Field: Mechanistic Basis and Clinical Implications. Clin Cancer Res. 2016; 22(15):3725-33. PMC: 4970897. DOI: 10.1158/1078-0432.CCR-16-0028. View

14.

Liu X, Lu Y, Xu Y, Hou S, Huang J, Wang B . Exosomal transfer of miR-501 confers doxorubicin resistance and tumorigenesis via targeting of BLID in gastric cancer. Cancer Lett. 2019; 459:122-134. DOI: 10.1016/j.canlet.2019.05.035. View

15.

Micke P, Ostman A . Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?. Lung Cancer. 2004; 45 Suppl 2:S163-75. DOI: 10.1016/j.lungcan.2004.07.977. View

16.

Mathai R, Vidya R, Reddy B, Thomas L, Udupa K, Kolesar J . Potential Utility of Liquid Biopsy as a Diagnostic and Prognostic Tool for the Assessment of Solid Tumors: Implications in the Precision Oncology. J Clin Med. 2019; 8(3). PMC: 6463095. DOI: 10.3390/jcm8030373. View

17.

Qian B, Pollard J . Macrophage diversity enhances tumor progression and metastasis. Cell. 2010; 141(1):39-51. PMC: 4994190. DOI: 10.1016/j.cell.2010.03.014. View

18.

Fu H, Yang H, Zhang X, Wang B, Mao J, Li X . Exosomal TRIM3 is a novel marker and therapy target for gastric cancer. J Exp Clin Cancer Res. 2018; 37(1):162. PMC: 6054744. DOI: 10.1186/s13046-018-0825-0. View

19.

Meehan K, Vella L . The contribution of tumour-derived exosomes to the hallmarks of cancer. Crit Rev Clin Lab Sci. 2015; 53(2):121-31. DOI: 10.3109/10408363.2015.1092496. View

20.

Anami K, Oue N, Noguchi T, Sakamoto N, Sentani K, Hayashi T . TSPAN8, identified by Escherichia coli ampicillin secretion trap, is associated with cell growth and invasion in gastric cancer. Gastric Cancer. 2015; 19(2):370-380. DOI: 10.1007/s10120-015-0478-z. View