Novel Roles of LSECtin in Gastric Cancer Cell Adhesion, Migration, Invasion, and Lymphatic Metastasis

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2022 Jul 13

PMID 35821222

Authors

Yinan Zhang

Zhen Feng

Yue Xu

Sufen Jiang

Qianshi Zhang

Zhenyu Zhang

Keyong Wang

Xiaomeng Li

Lijie Xu

Menglang Yuan

Zihao Chen

Jingyi Cui

Han Wu

Yina Gao

Wei Wei

Bo Wang

Yunfei Zuo

Shuangyi Ren

Affiliations

Soon will be listed here.

Abstract

Liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin) plays an important regulatory role in a variety of diseases, including tumors. However, the underlying mechanism of LSECtin in gastric cancer (GC) remains largely unknown. In our research, LSECtin promoted the adhesion and invasion of GC cells, and was involved in lymphatic metastasis of GC cells. Mechanistically, LSECtin promoted the adhesion, proliferation and migration of GC cells by downregulating STAT1 expression. The circular RNA circFBXL4, which is regulated by LSECtin, sponges the microRNA miR-146a-5p to regulate STAT1 expression. The promotion of GC cell proliferation, migration and invasion mediated by LSECtin was largely inhibited by circFBXL4 overexpression or miR-146a-5p silencing. Moreover, in its role as a transcription factor, STAT1 modulated the expression of FN1 and CHD4. In conclusion, LSECtin might be involved in the lymphatic metastasis of GC by upregulating the expression of FN1 and CHD4 via the circFBXL4/miR-146a-5p/STAT1 axis, possibly indicating a newly discovered pathogenic mechanism.

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