Epidemiology and Clinical Features of Adult Patients with Psoriasis in Malaysia: 10-Year Review from the Malaysian Psoriasis Registry (2007-2016)

Overview

Journal Dermatol Res Pract

Publisher Wiley

Specialty Dermatology

Date 2018 Jun 1

PMID 29849578

Citations 27

Authors

Azura Mohd Affandi

Iman Khan

Nooraishah Ngah Saaya

Affiliations

Soon will be listed here.

Abstract

Background: Psoriasis is a chronic inflammatory skin disease affecting 2-3% of the general population.

Aim: To evaluate the epidemiology and clinical characteristics of patients with psoriasis who seek treatment in outpatient dermatology clinics throughout hospitals in Malaysia.

Materials And Methods: Data were obtained from the Malaysian Psoriasis Registry (MPR). All patients (aged 18 and above) who were notified to the registry from July 2017 to December 2017 were included in this study.

Results: Among 15,794 patients, Malays were the most common (50.4%), followed by Chinese (21.4%), Indian (17.6%), and others (10.6%). The mean age onset of psoriasis for our study population was 35.14 ± 16.16 years. Male to female ratio was 1.3 : 1. 23.1% of patients had positive family history of psoriasis. The most common clinical presentation was chronic plaque psoriasis (85.1%), followed by guttate psoriasis (2.9%), erythrodermic psoriasis (1.7%), and pustular psoriasis (1.0%). Majority of our patients (76.6%) had a mild disease with BSA < 10%. 57.1% of patients had nail involvement, while arthropathy was seen in 13.7% of patients. Common triggers of the disease include stress (48.3%), sunlight (24.9%), and infection (9.1%). Comorbidities observed include obesity (24.3%), hypertension (25.6%), hyperlipidemia (18%), diabetes mellitus (17.2%), ischaemic heart disease (5.4%), and cerebrovascular disease (1.6%). The mean DLQI (Dermatology Life Quality Index) was 8.5 ± 6.6. One-third (33.1%) of the patients had a DLQI score of more than 10, while 14.2% of patients reported no effect at all.

Conclusion: Our study on the epidemiological data of adult patients with psoriasis in Malaysia showed a similar clinical profile and outcome when compared to international published studies on the epidemiology of psoriasis.

Citing Articles

Tanshinone I Ameliorates Psoriasis-Like Dermatitis by Suppressing Inflammation and Regulating Keratinocyte Differentiation.

Wang Q, Luo X, Su Y, Jin Y, Kuang Q, Li S Drug Des Devel Ther. 2025; 19:539-552.

PMID: 39876988 PMC: 11774251. DOI: 10.2147/DDDT.S504485.

Childhood guttate psoriasis: an updated review.

Leung A, Barankin B, Lam J, Leong K Drugs Context. 2023; 12.

PMID: 37908643 PMC: 10615329. DOI: 10.7573/dic.2023-8-2.

Antidepressants and the Risk of Psoriasis Induction: A Case-Control Study.

Sadatmadani S, Siadat A, Iraji F, Alsahebfosoul F Adv Biomed Res. 2023; 12:16.

PMID: 36926437 PMC: 10012025. DOI: 10.4103/abr.abr_88_21.

Scalp psoriasis and Dermatology Life Quality Index: A retrospective study based on 12-year data from the Malaysian Psoriasis Registry.

Leong W, Tang J Malays Fam Physician. 2023; 17(3):84-88.

PMID: 36606176 PMC: 9809430. DOI: 10.51866/oa.146.

Babchi Oil-Based Nanoemulsion Hydrogel for the Management of Psoriasis: A Novel Energy Economic Approach Employing Biosurfactants.

Alam A, Alqarni M, Foudah A, Raish M, Salkini M Gels. 2022; 8(12).

PMID: 36547285 PMC: 9777791. DOI: 10.3390/gels8120761.

References

Kane D, Stafford L, Bresnihan B, FitzGerald O . A prospective, clinical and radiological study of early psoriatic arthritis: an early synovitis clinic experience. Rheumatology (Oxford). 2003; 42(12):1460-8. DOI: 10.1093/rheumatology/keg384. View

Nyunt W, Low W, Ismail R, Sockalingam S, Min A . Determinants of health-related quality of life in psoriasis patients in Malaysia. Asia Pac J Public Health. 2013; 27(2):NP662-73. DOI: 10.1177/1010539513492561. View

Sinniah B, Saraswathy Devi S, Prashant B . Epidemiology of psoriasis in malaysia: a hospital based study. Med J Malaysia. 2013; 65(2):112-4. View

Finlay A, Khan G . Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. Clin Exp Dermatol. 1994; 19(3):210-6. DOI: 10.1111/j.1365-2230.1994.tb01167.x. View

Kurd S, Gelfand J . The prevalence of previously diagnosed and undiagnosed psoriasis in US adults: results from NHANES 2003-2004. J Am Acad Dermatol. 2008; 60(2):218-24. PMC: 4762027. DOI: 10.1016/j.jaad.2008.09.022. View

Icen M, Crowson C, McEvoy M, Dann F, Gabriel S, Kremers H . Trends in incidence of adult-onset psoriasis over three decades: a population-based study. J Am Acad Dermatol. 2009; 60(3):394-401. PMC: 3028518. DOI: 10.1016/j.jaad.2008.10.062. View

Gillard S, Finlay A . Current management of psoriasis in the United Kingdom: patterns of prescribing and resource use in primary care. Int J Clin Pract. 2005; 59(11):1260-7. DOI: 10.1111/j.1368-5031.2005.00680.x. View

Armstrong A, Harskamp C, Armstrong E . The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies. Nutr Diabetes. 2012; 2:e54. PMC: 3542430. DOI: 10.1038/nutd.2012.26. View

Tam L, Leung Y, Li E . Psoriatic arthritis in Asia. Rheumatology (Oxford). 2009; 48(12):1473-7. DOI: 10.1093/rheumatology/kep230. View

10.

Gladman D, Mease P, Strand V, Healy P, Helliwell P, FitzGerald O . Consensus on a core set of domains for psoriatic arthritis. J Rheumatol. 2007; 34(5):1167-70. View

11.

Bo K, Thoresen M, Dalgard F . Smokers report more psoriasis, but not atopic dermatitis or hand eczema: results from a Norwegian population survey among adults. Dermatology. 2007; 216(1):40-5. DOI: 10.1159/000109357. View

12.

Henseler T, Christophers E . Psoriasis of early and late onset: characterization of two types of psoriasis vulgaris. J Am Acad Dermatol. 1985; 13(3):450-6. DOI: 10.1016/s0190-9622(85)70188-0. View

13.

Buske-Kirschbaum A, Ebrecht M, Kern S, Hellhammer D . Endocrine stress responses in TH1-mediated chronic inflammatory skin disease (psoriasis vulgaris)--do they parallel stress-induced endocrine changes in TH2-mediated inflammatory dermatoses (atopic dermatitis)?. Psychoneuroendocrinology. 2005; 31(4):439-46. DOI: 10.1016/j.psyneuen.2005.10.006. View

14.

Ding X, Wang T, Shen Y, Wang X, Zhou C, Tian S . Prevalence of psoriasis in China: a population-based study in six cities. Eur J Dermatol. 2012; 22(5):663-7. DOI: 10.1684/ejd.2012.1802. View

15.

Perera G, Di Meglio P, Nestle F . Psoriasis. Annu Rev Pathol. 2011; 7:385-422. DOI: 10.1146/annurev-pathol-011811-132448. View

16.

Wilson F, Icen M, Crowson C, McEvoy M, Gabriel S, Kremers H . Incidence and clinical predictors of psoriatic arthritis in patients with psoriasis: a population-based study. Arthritis Rheum. 2009; 61(2):233-9. PMC: 3061343. DOI: 10.1002/art.24172. View

17.

Lonnberg A, Skov L, Skytthe A, Kyvik K, Pedersen O, Thomsen S . Smoking and risk for psoriasis: a population-based twin study. Int J Dermatol. 2015; 55(2):e72-8. DOI: 10.1111/ijd.13073. View

18.

Moll J, WRIGHT V . Psoriatic arthritis. Semin Arthritis Rheum. 1973; 3(1):55-78. DOI: 10.1016/0049-0172(73)90035-8. View

19.

Cohen A, Sherf M, Vidavsky L, Vardy D, Shapiro J, Meyerovitch J . Association between psoriasis and the metabolic syndrome. A cross-sectional study. Dermatology. 2008; 216(2):152-5. DOI: 10.1159/000111512. View

20.

Seminara N, Abuabara K, Shin D, Langan S, Kimmel S, Margolis D . Validity of The Health Improvement Network (THIN) for the study of psoriasis. Br J Dermatol. 2010; 164(3):602-9. PMC: 3064479. DOI: 10.1111/j.1365-2133.2010.10134.x. View