Psoriasis

Overview

Journal Annu Rev Pathol

Publisher Annual Reviews

Specialty Pathology

Date 2011 Nov 8

PMID 22054142

Citations 211

Authors

Gayathri K Perera

Paola Di Meglio

Frank O Nestle

Affiliations

Soon will be listed here.

Abstract

Psoriasis is a common relapsing and remitting immune-mediated inflammatory disease that affects the skin and joints. This review focuses on current immunogenetic concepts, key cellular players, and axes of cytokines that are thought to contribute to disease pathogenesis. We highlight potential therapeutic targets and give an overview of the currently used immune-targeted therapies.

Citing Articles

A Novel Immune-Related Three-Gene Signature and Immune Infiltration Insights in Psoriasis and Chronic Kidney Disease.

Yin T, Zhang T, Ma L Clin Cosmet Investig Dermatol. 2025; 18:267-286.

PMID: 39881853 PMC: 11776511. DOI: 10.2147/CCID.S499202.

Roles for Exosomes in the Pathogenesis, Drug Delivery and Therapy of Psoriasis.

Chen Y, Liu H, He Y, Yang B, Lu W, Dai Z Pharmaceutics. 2025; 17(1).

PMID: 39861699 PMC: 11768235. DOI: 10.3390/pharmaceutics17010051.

The role of the STING inflammatory pathway in hepatic damage in psoriasis with type 2 diabetes mellitus.

Huang S, Xie K, Li X, Xu X, Chen P Arch Med Sci. 2024; 20(5):1426-1441.

PMID: 39649265 PMC: 11623156. DOI: 10.5114/aoms/183672.

The interplay between epidermal barrier distribution, microbiota composition, and immune infiltrate defines and stratifies psoriasis patients and is associated with disease severity.

Ortega Rocha E, Hernandez-Herrera P, de Los Santos-Carmona S, De Leon-Rodriguez S, Juarez-Flores A, Perez-Koldenkova V J Transl Autoimmun. 2024; 9:100257.

PMID: 39582772 PMC: 11584942. DOI: 10.1016/j.jtauto.2024.100257.

Profiling CARD14 gene expression in Indian Psoriasis patients.

Singh S, Pradhan D, Puri P, Sharma S, Jain A Sci Rep. 2024; 14(1):28798.

PMID: 39567556 PMC: 11579362. DOI: 10.1038/s41598-024-78267-9.