Genetics of Psoriasis: a Basis for Precision Medicine

Overview

Journal Precis Clin Med

Publisher Oxford University Press

Specialty General Medicine

Date 2022 Jun 13

PMID 35693758

Authors

Delin Ran

Minglong Cai

Xuejun Zhang

Affiliations

Soon will be listed here.

Abstract

Psoriasis is an inflammatory skin disease with a background of polygenic inheritance. Both environmental and genetic factors are involved in the etiology of the disease. In the last two decades, numerous studies have been conducted through linkage analysis, genome-wide association study (GWAS), and direct sequencing to explore the role of genetic variation in disease pathogenesis and progression. To date, >80 psoriasis susceptibility genes have been identified, including , , , and . Some genetic markers have been applied in disease prediction, clinical diagnosis, treatment, and new drug development, which could further explain the pathogenesis of psoriasis and promote the development of precision medicine. This review summarizes related research on genetic variation in psoriasis and explores implications of the findings in clinical application and the promotion of a personalized medicine project.

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