Associations Between Plasmatic Polyunsaturated Fatty Acids Concentrations and Cognitive Status and Decline in Neurocognitive Disorders

Overview

Journal J Nutr Health Aging

Specialties Geriatrics
Nutritional Sciences

Date 2018 May 29

PMID 29806861

Citations 4

Authors

M Haution-Bitker

T Gilbert

A Vignoles

C Lecardonnel

S Watelet

E Blond

J Drai

M Bonnefoy

Affiliations

Soon will be listed here.

Abstract

Objective: To examine the association of plasmatic and erythrocyte concentrations polyunsaturated fatty acids (PUFA) with both cognitive status and decline.

Design: Longitudinal observational cohort study.

Setting: Memory Clinic of Lyon Sud university hospital.

Participants: 140 patients, aged 60 and older, were referred to the memory clinic, and successively included in the cohort, between March 2010 and February 2014.

Measurements: Concentration of ω-3 PUFA (eicosapentaenoic: EPA and docosahexaenoic: DHA) and ω-6 PUFA (arachidonic: AA), were measured at baseline in plasma and in the erythrocytes membrane. Cognitive status was assessed using the mini mental state examination (MMSE), at baseline and every six months during follow-up. The median follow-up period was of 11,5 months.

Results: Compared to participants with minor neurocognitive disorders (MMSE≥24), participants with major neurocognitive disorders (NCD) had lower plasmatic concentrations of EPA and DHA (p<0.05) at baseline. Erythrocyte AA and DHA concentrations were significantly lower in patients with cognitive decline (defined as a ≥2 points loss of MMSE per year), while no difference in plasmatic concentrations was observed.

Conclusions: Our study suggests that ω-3 PUFA plasma concentrations (mainly EPA and DHA) could be associated with cognitive status in older people. Moreover, in this exploratory study, lower erythrocyte PUFA concentrations (AA and DHA) were associated with accelerated decline and could be proposed as a surrogate marker for prediction of cognitive decline.

Citing Articles

Cognitive Function After Stopping Folic Acid and DHA Intervention: An Extended Follow-Up Results from the Randomized, Double Blind, Placebo-Controlled Trial in Older Adults with Mild Cognitive Impairment.

Bai D, Fan J, Li M, Dong C, Gao Y, Fu M J Alzheimers Dis Rep. 2024; 8(1):1285-1295.

PMID: 39434820 PMC: 11491953. DOI: 10.3233/ADR-240033.

The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, and Blood Markers.

Wei B, Li L, Dong C, Tan C, Xu W Am J Clin Nutr. 2023; 117(6):1096-1109.

PMID: 37028557 PMC: 10447496. DOI: 10.1016/j.ajcnut.2023.04.001.

Association between the Erythrocyte Membrane Fatty Acid Profile and Cognitive Function in the Overweight and Obese Population Aged from 45 to 75 Years Old.

Shen J, Li J, Hua Y, Ding B, Zhou C, Yu H Nutrients. 2022; 14(4).

PMID: 35215564 PMC: 8878599. DOI: 10.3390/nu14040914.

Childhood growth and neurocognition are associated with distinct sets of metabolites.

Moreau G, Ramakrishnan G, Cook H, Fox T, Nayak U, Ma J EBioMedicine. 2019; 44:597-606.

PMID: 31133540 PMC: 6604877. DOI: 10.1016/j.ebiom.2019.05.043.

References

Yanai H . Effects of N-3 Polyunsaturated Fatty Acids on Dementia. J Clin Med Res. 2016; 9(1):1-9. PMC: 5127208. DOI: 10.14740/jocmr2815w. View

DAscoli T, Mursu J, Voutilainen S, Kauhanen J, Tuomainen T, Virtanen J . Association between serum long-chain omega-3 polyunsaturated fatty acids and cognitive performance in elderly men and women: The Kuopio Ischaemic Heart Disease Risk Factor Study. Eur J Clin Nutr. 2016; 70(8):970-5. DOI: 10.1038/ejcn.2016.59. View

Tully A, Roche H, Doyle R, Fallon C, Bruce I, Lawlor B . Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study. Br J Nutr. 2003; 89(4):483-9. DOI: 10.1079/BJN2002804. View

Yin Y, Fan Y, Lin F, Xu Y, Zhang J . Nutrient biomarkers and vascular risk factors in subtypes of mild cognitive impairment: a cross-sectional study. J Nutr Health Aging. 2015; 19(1):39-47. DOI: 10.1007/s12603-014-0510-8. View

Sachdev P, Mohan A, Taylor L, Jeste D . DSM-5 and Mental Disorders in Older Individuals: An Overview. Harv Rev Psychiatry. 2015; 23(5):320-8. PMC: 4562208. DOI: 10.1097/HRP.0000000000000090. View

Revel F, Gilbert T, Roche S, Drai J, Blond E, Ecochard R . Influence of oxidative stress biomarkers on cognitive decline. J Alzheimers Dis. 2015; 45(2):553-60. DOI: 10.3233/JAD-141797. View

Hodson L, Skeaff C, Fielding B . Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res. 2008; 47(5):348-80. DOI: 10.1016/j.plipres.2008.03.003. View

Lopes da Silva S, Vellas B, Elemans S, Luchsinger J, Kamphuis P, Yaffe K . Plasma nutrient status of patients with Alzheimer's disease: Systematic review and meta-analysis. Alzheimers Dement. 2013; 10(4):485-502. DOI: 10.1016/j.jalz.2013.05.1771. View

Huang M, Brenna J, Chao A, Tschanz C, Diersen-Schade D, Hung H . Differential tissue dose responses of (n-3) and (n-6) PUFA in neonatal piglets fed docosahexaenoate and arachidonoate. J Nutr. 2007; 137(9):2049-55. DOI: 10.1093/jn/137.9.2049. View

10.

Brenner S . Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging. Neurology. 2012; 79(1):106. DOI: 10.1212/WNL.0b013e31825e41b2. View

11.

Whalley L, Deary I, Starr J, Wahle K, Rance K, Bourne V . n-3 Fatty acid erythrocyte membrane content, APOE varepsilon4, and cognitive variation: an observational follow-up study in late adulthood. Am J Clin Nutr. 2008; 87(2):449-54. DOI: 10.1093/ajcn/87.2.449. View

12.

Fougere B, De Souto Barreto P, Goisser S, Soriano G, Guyonnet S, Andrieu S . Red blood cell membrane omega-3 fatty acid levels and physical performance: Cross-sectional data from the MAPT study. Clin Nutr. 2017; 37(4):1141-1144. DOI: 10.1016/j.clnu.2017.04.005. View

13.

Hooper C, De Souto Barreto P, Payoux P, Salabert A, Guyonnet S, Andrieu S . Cross-sectional associations of cortical β-amyloid with erythrocyte membrane long-chain polyunsaturated fatty acids in older adults with subjective memory complaints. J Neurochem. 2017; 142(4):589-596. DOI: 10.1111/jnc.14062. View

14.

Folch J, ASCOLI I, Lees M, MEATH J, LeBARON N . Preparation of lipide extracts from brain tissue. J Biol Chem. 1951; 191(2):833-41. View

15.

Solfrizzi V, Capurso C, DIntrono A, Colacicco A, Frisardi V, Santamato A . Dietary fatty acids, age-related cognitive decline, and mild cognitive impairment. J Nutr Health Aging. 2008; 12(6):382-6. DOI: 10.1007/BF02982670. View

16.

Heude B, Ducimetiere P, Berr C . Cognitive decline and fatty acid composition of erythrocyte membranes--The EVA Study. Am J Clin Nutr. 2003; 77(4):803-8. DOI: 10.1093/ajcn/77.4.803. View

17.

Scarmeas N, Stern Y, Tang M, Mayeux R, Luchsinger J . Mediterranean diet and risk for Alzheimer's disease. Ann Neurol. 2006; 59(6):912-21. PMC: 3024594. DOI: 10.1002/ana.20854. View

18.

Folstein M, Folstein S, McHugh P . "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12(3):189-98. DOI: 10.1016/0022-3956(75)90026-6. View

19.

Cederholm T, Salem Jr N, Palmblad J . ω-3 fatty acids in the prevention of cognitive decline in humans. Adv Nutr. 2013; 4(6):672-6. PMC: 3823515. DOI: 10.3945/an.113.004556. View

20.

Cui Y, Chen X, Liu L, Xie W, Wu Y, Wu Q . Gas chromatography-mass spectrometry analysis of the free fatty acids in serum obtained from patients with Alzheimer's disease. Biomed Mater Eng. 2015; 26 Suppl 1:S2165-77. DOI: 10.3233/BME-151522. View