Modeling Mammalian Gastrulation With Embryonic Stem Cells

Overview

Journal Curr Top Dev Biol

Publisher Elsevier

Specialties Biology
Reproductive Medicine

Date 2018 May 27

PMID 29801527

Citations 15

Authors

Eric D Siggia

Aryeh Warmflash

Affiliations

Soon will be listed here.

Abstract

Understanding cell fate patterning and morphogenesis in the mammalian embryo remains a formidable challenge. Recently, in vivo models based on embryonic stem cells (ESCs) have emerged as complementary methods to quantitatively dissect the physical and molecular processes that shape the embryo. Here we review recent developments in using ESCs to create both two- and three-dimensional culture models that shed light on mammalian gastrulation.

Citing Articles

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Early human development and stem cell-based human embryo models.

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