Towards a Complete Map of the Human Long Non-coding RNA Transcriptome

Overview

Journal Nat Rev Genet

Specialty Genetics

Date 2018 May 26

PMID 29795125

Citations 312

Authors

Barbara Uszczynska-Ratajczak

Julien Lagarde

Adam Frankish

Roderic Guigo

Rory Johnson

Affiliations

Soon will be listed here.

Abstract

Gene maps, or annotations, enable us to navigate the functional landscape of our genome. They are a resource upon which virtually all studies depend, from single-gene to genome-wide scales and from basic molecular biology to medical genetics. Yet present-day annotations suffer from trade-offs between quality and size, with serious but often unappreciated consequences for downstream studies. This is particularly true for long non-coding RNAs (lncRNAs), which are poorly characterized compared to protein-coding genes. Long-read sequencing technologies promise to improve current annotations, paving the way towards a complete annotation of lncRNAs expressed throughout a human lifetime.

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