Alternative Splicing As a Regulator of Development and Tissue Identity

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2017 May 11

PMID 28488700

Citations 643

Authors

Francisco E Baralle

Jimena Giudice

Affiliations

Soon will be listed here.

Abstract

Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a limited number of genes. The mechanisms and outcomes of alternative splicing of individual transcripts are relatively well understood, and recent efforts have been directed towards studying splicing networks. It has become apparent that coordinated splicing networks regulate tissue and organ development, and that alternative splicing has important physiological functions in different developmental processes in humans.

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