» Articles » PMID: 37233176

The Role of Vitamin D in Reducing the Risk of Metabolic Disturbances That Cause Cardiovascular Diseases

Overview
Authors
Affiliations
Soon will be listed here.
Abstract

Among the most common problems facing public health today is a lack of vitamin D, which plays a role in the physiological processes of chronic illness conditions. Vitamin D deficiency in metabolic disorders has primary effects on osteoporosis, obesity, hypertension, diabetes, and cardiovascular disease (CVD). Vitamin D acts as a "co-hormone" in the various tissues of the body, and it has been found that vitamin D receptors (VDR) are present on all cell types, suggesting that vitamin D has a wide range of effects on most cells. Recently, there has been a surge in interest in assessing its roles. Vitamin D insufficiency increases the risk of diabetes because it lowers insulin sensitivity, and also raises the risk of obesity and CVD because of its effect on the body's lipid profile, particularly in terms of the prevalence of dangerously high levels of low-density lipoproteins (LDL). Furthermore, vitamin D insufficiency is often related to CVD and connected risk factors, highlighting the need to know vitamin D's functions in relation to metabolic syndrome and related processes. Through looking at previous studies, this paper explains why vitamin D is important, how deficiency is related to risk factors for metabolic syndrome through different mechanisms, and how deficiency affects CVD.

Citing Articles

Vitamin D: Beyond Traditional Roles-Insights into Its Biochemical Pathways and Physiological Impacts.

Voiculescu V, Nelson Twakor A, Jerpelea N, Pantea Stoian A Nutrients. 2025; 17(5).

PMID: 40077673 PMC: 11902150. DOI: 10.3390/nu17050803.


Prevalence of Vitamin D Deficiency Among Adults in Kazakhstan: A Systematic Review and Meta-Analysis.

Karibayeva I, Bilibayeva G, Yerzhanova A, Alekesheva R, Iglikova A, Maxudova M Medicina (Kaunas). 2025; 60(12.

PMID: 39768922 PMC: 11727896. DOI: 10.3390/medicina60122043.


The impact of the COVID-19 pandemic on burnout levels among healthcare workers: A comparative analysis of the pandemic period and post-pandemic period.

Reshetnikov A, Abaeva O, Prisyazhnaya N, Romanova T, Romanov S, Sobolev K Heliyon. 2024; 10(17):e36769.

PMID: 39286130 PMC: 11402927. DOI: 10.1016/j.heliyon.2024.e36769.


Investigating the Effects and Mechanisms of Combined Vitamin D and K Supplementation in Postmenopausal Women: An Up-to-Date Comprehensive Review of Clinical Studies.

Rusu M, Bigman G, Ryan A, Popa D Nutrients. 2024; 16(14.

PMID: 39064799 PMC: 11279569. DOI: 10.3390/nu16142356.


Association between serum vitamin D levels and lipid profiles: a cross-sectional analysis.

Gholamzad A, Khakpour N, Kabipour T, Gholamzad M Sci Rep. 2023; 13(1):21058.

PMID: 38030665 PMC: 10687006. DOI: 10.1038/s41598-023-47872-5.


References
1.
Rostand S, Drueke T . Parathyroid hormone, vitamin D, and cardiovascular disease in chronic renal failure. Kidney Int. 1999; 56(2):383-92. DOI: 10.1046/j.1523-1755.1999.00575.x. View

2.
Wongdee K, Charoenphandhu N . Vitamin D-enhanced duodenal calcium transport. Vitam Horm. 2015; 98:407-40. DOI: 10.1016/bs.vh.2014.12.010. View

3.
Haybar H, Shahrabi S, Rezaeeyan H, Shirzad R, Saki N . Endothelial Cells: From Dysfunction Mechanism to Pharmacological Effect in Cardiovascular Disease. Cardiovasc Toxicol. 2018; 19(1):13-22. DOI: 10.1007/s12012-018-9493-8. View

4.
Vassalle C, Parlanti A, Pingitore A, Berti S, Iervasi G, Sabatino L . Vitamin D, Thyroid Hormones and Cardiovascular Risk: Exploring the Components of This Novel Disease Triangle. Front Physiol. 2021; 12:722912. PMC: 8481379. DOI: 10.3389/fphys.2021.722912. View

5.
Pingitore A, Mastorci F, Berti S, Sabatino L, Palmieri C, Iervasi G . Hypovitaminosis D and Low T3 Syndrome: A Link for Therapeutic Challenges in Patients with Acute Myocardial Infarction. J Clin Med. 2021; 10(22). PMC: 8625651. DOI: 10.3390/jcm10225267. View