KCNQ1OT1 Promotes Melanoma Growth and Metastasis

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2018 Apr 19

PMID 29667930

Citations 24

Authors

Bingyu Guo

Qian Zhang

Hongyi Wang

Peng Chang

Kai Tao

Affiliations

Soon will be listed here.

Abstract

Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demonstrated that KCNQ1OT1 expression is up-regulated in melanoma tissues and cells. KCNQ1OT1 promoted cell proliferation and metastasis in melanoma. By directly bindin to miR-153, KCNQ1OT1 acted as a competing endogenous RNA (ceRNA) to de-repress MET expression. Our results may provide the basis for a novel strategy for early detection and/or treatment of melanoma.

Citing Articles

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