The Functional Role of Long Non-Coding RNAs in Melanoma

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2021 Oct 13

PMID 34638331

Citations 10

Authors

Michal Wozniak

Malgorzata Czyz

Affiliations

Soon will be listed here.

Abstract

Melanoma is the most lethal skin cancer, with increasing incidence worldwide. The molecular events that drive melanoma development and progression have been extensively studied, resulting in significant improvements in diagnostics and therapeutic approaches. However, a high drug resistance to targeted therapies and adverse effects of immunotherapies are still a major challenge in melanoma treatment. Therefore, the elucidation of molecular mechanisms of melanomagenesis and cancer response to treatment is of great importance. Recently, many studies have revealed the close association of long noncoding RNAs (lncRNAs) with the development of many cancers, including melanoma. These RNA molecules are able to regulate a plethora of crucial cellular processes including proliferation, differentiation, migration, invasion and apoptosis through diverse mechanisms, and even slight dysregulation of their expression may lead to tumorigenesis. lncRNAs are able to bind to protein complexes, DNA and RNAs, affecting their stability, activity, and localization. They can also regulate gene expression in the nucleus. Several functions of lncRNAs are context-dependent. This review summarizes current knowledge regarding the involvement of lncRNAs in melanoma. Their possible role as prognostic markers of melanoma response to treatment and in resistance to therapy is also discussed.

Citing Articles

Unravelling the Regulatory Roles of lncRNAs in Melanoma: From Mechanistic Insights to Target Selection.

Moras B, Sissi C Int J Mol Sci. 2025; 26(5).

PMID: 40076754 PMC: 11900516. DOI: 10.3390/ijms26052126.

Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues.

Vo T, Prakrithi P, Jones K, Yoon S, Lam P, Kao Y J Pathol. 2025; 265(3):274-288.

PMID: 39846232 PMC: 11794982. DOI: 10.1002/path.6383.

LncRNAs in melanoma phenotypic plasticity: emerging targets for promising therapies.

Beatriz Cristina Biz T, Carolina de Sousa C, Frank John S, Miriam Galvonas J RNA Biol. 2024; 21(1):81-93.

PMID: 39498940 PMC: 11540095. DOI: 10.1080/15476286.2024.2421672.

A New Approach to Melanoma Treatment: microRNAs.

Ilhan S, Oguz F, Atmaca H Curr Top Med Chem. 2024; 24(16):1362-1376.

PMID: 38676490 DOI: 10.2174/0115680266291290240417081544.

YY1-induced lncRNA00511 promotes melanoma progression via the miR-150-5p/ADAM19 axis.

Chen Y, Fu X, Guo H, Fu X, Shi K, Gao T Am J Cancer Res. 2024; 14(2):809-831.

PMID: 38455406 PMC: 10915319.

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