Triggerable Multivalent Glyconanoparticles for Probing Carbohydrate-Carbohydrate Interactions

Overview

Journal ACS Macro Lett

Publisher American Chemical Society

Specialty Chemistry

Date 2018 Apr 17

PMID 29657901

Citations 5

Authors

Sangho Won

Steven Hindmarsh

Matthew I Gibson

Affiliations

Soon will be listed here.

Abstract

Carbohydrate-carbohydrate interactions are proposed to be biologically significant but have lower affinities than the well-studied carbohydrate-protein interactions. Here we introduce multivalent glyconanostructures where the surface expression of lactose can be triggered by an external stimulus, and a gold nanoparticle core enables colorimetric signal outputs to probe binding. Macromolecular engineering of a responsive polymer "gate" enables the lactose moieties to be presented only when an external stimulus is present, mimicking how nature uses enzymes to dynamically regulate glycan expression. Two different carbohydrate-carbohydrate interactions are investigated using this tool.

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