Hox Genes in Cardiovascular Development and Diseases

Overview

Journal J Dev Biol

Specialty Biology

Date 2018 Apr 5

PMID 29615581

Citations 23

Authors

Marine Roux

Stephane Zaffran

Affiliations

Soon will be listed here.

Abstract

Congenital heart defects (CHD) are the leading cause of death in the first year of life. Over the past 20 years, much effort has been focused on unraveling the genetic bases of CHD. In particular, studies in human genetics coupled with those of model organisms have provided valuable insights into the gene regulatory networks underlying CHD pathogenesis. genes encode transcription factors that are required for the patterning of the anterior-posterior axis in the embryo. In this review, we focus on the emerging role of anteriorly expressed genes (, , and ) in cardiac development, specifically their contribution to patterning of cardiac progenitor cells and formation of the great arteries. Recent evidence regarding the cooperative regulation of heart development by Hox proteins with members of the TALE-class of homeodomain proteins such as Pbx and Meis transcription factors is also discussed. These findings are highly relevant to human pathologies as they pinpoint new genes that increase susceptibility to cardiac anomalies and provide novel mechanistic insights into CHD.

Citing Articles

Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac pathology and early indicators of cardiac risk.

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