Chronic nicotinamide Riboside Supplementation is Well-tolerated and Elevates NAD in Healthy Middle-aged and Older Adults

Overview

Journal Nat Commun

Specialty Biology

Date 2018 Mar 31

PMID 29599478

Citations 273

Authors

Christopher R Martens

Blair A Denman

Melissa R Mazzo

Michael L Armstrong

Nichole Reisdorph

Matthew B McQueen

Michel Chonchol

Douglas R Seals

Affiliations

Soon will be listed here.

Abstract

Nicotinamide adenine dinucleotide (NAD) has emerged as a critical co-substrate for enzymes involved in the beneficial effects of regular calorie restriction on healthspan. As such, the use of NAD precursors to augment NAD bioavailability has been proposed as a strategy for improving cardiovascular and other physiological functions with aging in humans. Here we provide the evidence in a 2 × 6-week randomized, double-blind, placebo-controlled, crossover clinical trial that chronic supplementation with the NAD precursor vitamin, nicotinamide riboside (NR), is well tolerated and effectively stimulates NAD metabolism in healthy middle-aged and older adults. Our results also provide initial insight into the effects of chronic NR supplementation on physiological function in humans, and suggest that, in particular, future clinical trials should further assess the potential benefits of NR for reducing blood pressure and arterial stiffness in this group.

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